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Giovanni Sarnelli et al.
Phytotherapy research : PTR, 30(6), 963-970 (2016-03-02)
Palmitoylethanolamide (PEA) is a nutraceutical compound that has been demonstrated to improve intestinal inflammation. We aimed at evaluating its antiproliferative and antiangiogenic effects in human colon adenocarcinoma Caco-2 cell line. Caco-2 cells were treated with increasing concentrations of PEA (0.001
Araceli Valverde et al.
PloS one, 10(6), e0131363-e0131363 (2015-06-25)
Despite the demonstrated benefits of anti-EGFR/VEGF targeted therapies in metastatic colorectal cancer (mCRC), many patients initially respond, but then show evidence of disease progression. New therapeutic strategies are needed to make the action of available drugs more efficient. Our study
J Fogh et al.
Journal of the National Cancer Institute, 58(2), 209-214 (1977-02-01)
Numerous cell lines derived from human tumors are not HeLa contaminants. Of 192 lines established in this or other laboratories, 169 lines were found to be G6PD type B. Twenty-three lines were type A as HeLa; three of these were
A Adachi et al.
Journal of virology, 61(1), 209-213 (1987-01-01)
Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible.
Isabel Seiquer et al.
Food chemistry, 188, 496-503 (2015-06-05)
Argan oil is becoming increasingly popular in the edible-oil market as a luxury food with healthy properties. This paper analyzes (i) the bioavailability of the polyphenol content and antioxidant properties of extra virgin argan oil (EVA) by the combination of
Sílvia A Moreira et al.
Food & function, 11(1), 921-931 (2020-01-18)
Stinging nettle is traditionally used as a therapeutic herb. In the present work, the biological properties and toxicity of novel nettle leaf extracts obtained by high pressure assisted extraction (HPE) were studied and compared with similar extracts obtained with the
Yasuo Uchida et al.
Drug metabolism and pharmacokinetics, 30(2), 205-208 (2015-03-15)
The purpose of the present study was to evaluate and compare the absolute protein expression levels of 28 drug-related transporters in Caco-2 cell monolayers cultured for 2, 3, and 4 weeks. Plasma membrane fractions of Caco-2 cells cultured on Transwell
Biopharmaceutical classification of desloratadine-not all drugs are classified the easy way
Berginc K, et al.
Acta pharmaceutica (Zagreb, Croatia), 70, 131-144 (2020)
Imtiyaz Thagia et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(1), G25-G31 (2014-11-08)
A single layer of intestinal epithelial cells (IEC) lines the entire gastrointestinal tract and provides the first line of defense and barrier against an abundance of microbial stimuli. IEC homeostasis and repair are mediated through microbe-sensing Toll-like receptor (TLR)-induced inflammatory
Antonella Rosa et al.
Nutrients, 7(2), 849-864 (2015-01-30)
The present study aimed to examine the potential anticancer properties of fixed oil obtained from Maltese mushroom (Cynomorium coccineum L.), an edible, non-photosynthetic plant, used in traditional medicine of Mediterranean countries to treat various ailments and as an emergency food
Giuseppe Esposito et al.
Frontiers in pharmacology, 7, 120-120 (2016-06-01)
Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat. The study aimed to evaluate the effect of rifaximin on TcdA-induced apoptosis in intestinal
Eszter Róka et al.
Molecules (Basel, Switzerland), 20(11), 20269-20285 (2015-11-17)
Cyclodextrins, even the 6-membered α-cyclodextrin, are approved in the various pharmacopoeias as pharmaceutical excipients for solubilizing and stabilizing drugs as well as for controlling drug release. Recently α-cyclodextrin has also been marketed as health food with beneficial effects on blood
Violeta Lorén et al.
PloS one, 10(6), e0130921-e0130921 (2015-06-20)
Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment. Previously, we reported that low IL-10 mRNA levels in intestine are associated with a
J Fogh et al.
Journal of the National Cancer Institute, 59(1), 221-226 (1977-07-01)
One hundred and twenty-seven cultured human tumor cell lines produced tumors after sc inoculation of 1-20 million cells into nude mice. They included 56 carcinoma lines, 14 sarcoma lines, and 57 lines from miscellaneous tumors and were all glucose-6-phosphate dehydrogenase
D L Trainer et al.
International journal of cancer, 41(2), 287-296 (1988-02-15)
To establish well-characterized cellular reagents for the study of colon carcinoma, we have examined 19 human colorectal carcinoma cell lines with regard to morphology, ultrastructure, expression of tumor-associated antigens, proliferative capacity in vitro, anchorage-independent growth, oncogene expression, tumorigenicity and malignant
M Lautenschläger et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 22(1), 36-44 (2015-02-01)
Extracts of saffron (Crocus sativus L.) have traditionally been used against depressions. Recent preclinical and clinical investigations have rationalized this traditional use. Trans-crocetin, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity
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