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Mingxiang Ye et al.
Cancer letters, 357(1), 196-205 (2014-12-03)
Curcumin has attracted increasing interest as an anti-cancer drug for decades. The mechanisms of action involve multiple cancer-related signaling pathways. Recent studies highlighted curcumin has epigenetic regulatory effects on miRNA in cancers. In the present study, we demonstrated the proapoptotic...
Shusuke Toden et al.
Carcinogenesis, 36(3), 355-367 (2015-02-06)
Resistance to cytotoxic chemotherapy is a major cause of mortality in colorectal cancer (CRC) patients. Chemoresistance has been linked primarily to a subset of cancer cells undergoing epithelial-mesenchymal transition (EMT). Curcumin, a botanical with antitumorigenic properties, has been shown to...
Rana Tarzemany et al.
PloS one, 10(1), e0115524-e0115524 (2015-01-15)
Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression...
Bopaiah Cheppudira et al.
Expert opinion on investigational drugs, 22(10), 1295-1303 (2013-08-02)
Managing burn injury-associated pain and wounds is a major unresolved clinical problem. Opioids, nonsteroidal antiinflammatory drugs (NSAIDs), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. However, prolonged treatment with these drugs leads to...
Investigations of curcumin and resveratrol on neurite outgrowth: perspectives on spinal muscular atrophy.
Bora-Tatar G, Erdem-Yurter H, et al.
BioMed Research International, 2014, 709108-709108 (2014)
Thitita Unahabhokha et al.
Pharmaceutical biology, 53(3), 457-463 (2014-10-22)
Keloid is an excessive dermal scar occurring in response to skin injuries. Several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. Even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways...
Kunal Jain et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 17(5), 579-591 (2013-08-03)
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological...
Hongbin Ni et al.
The Journal of surgical research, 187(2), 646-652 (2014-02-04)
The present study aimed to investigate the effects of curcumin on the levels of spinal cord labile zinc (Zn) and inflammatory cytokines in rats after traumatic spinal cord injury (SCI). Adult male Sprague-Dawley rats were subjected to laminectomy at T8-T9...
Mei Dai et al.
Journal of biomedicine & biotechnology, 2009, 595126-595126 (2009-11-18)
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability...
Job C Tharappel et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(11), 3467-3474 (2008-09-18)
Polychlorinated biphenyls (PCBs) have promoting activity in the liver, which may be brought about in part by the induction of oxidative stress. In this study we examined the effects of several antioxidant phytochemicals on the tumor promoting activity of 3,3',4'4-tetrachlorobiphenyl...
Huijin Fan et al.
Targeted oncology, 9(3), 279-286 (2013-07-04)
Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including liver cancer. Curcumin is the major active ingredient of Curcuma longa and has long been used to treat a variety of maladies. In the present study...
Daijiro Yanagisawa et al.
Neurobiology of aging, 36(1), 201-210 (2014-09-03)
Recent evidence supports the amyloid cascade hypothesis that a pathological change of amyloid β (Aβ) in the brain is an initiating event in Alzheimer's disease (AD). Accordingly, modulating the abnormal Aβ aggregation is considered a potential therapeutic target in AD....
Mona Fouad Mahmoud et al.
Pharmaceutical biology, 52(8), 972-977 (2014-03-13)
Consumption of high fructose is associated with metabolic abnormalities, insulin resistance, and hypertension. It is not known whether this hypertensive effect of fructose is related to metabolic abnormalities or due to the direct effect of fructose on blood vessels. Here...
Tzu-Hua Lin et al.
The Journal of biological chemistry, 288(27), 19359-19369 (2013-05-21)
Despite the fact that androgen deprivation therapy (ADT) can effectively reduce prostate cancer (PCa) size, its effect on PCa metastasis remains unclear. We examined the existing data on PCa patients treated with ADT plus anti-androgens to analyze ADT effects on...
Deyan Y Yosifov et al.
Leukemia research, 38(1), 49-56 (2013-11-15)
While most patients with early-stage cutaneous T-cell lymphomas (CTCL) have a very good prognosis, the survival of patients with extensive tumour stage and visceral involvement remains extremely poor and necessitates the development of more effective treatment modalities. In this study...
Phyllis Langone et al.
International journal of cancer, 135(3), 710-719 (2013-10-22)
Current therapies for glioblastoma are largely palliative, involving surgical resection followed by chemotherapy and radiation therapy, which yield serious side effects and very rarely produce complete recovery. Curcumin, a food component, blocked brain tumor formation but failed to eliminate established...
Deepak Yadav et al.
International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)
The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters...
Elena Creţu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(4), 1223-1229 (2013-05-25)
Nowadays cancer is still a major public health issue. Despite all the progresses made in cancer prevention, diagnosis and treatment, mortality by cancer is on the second place after the one caused by cardiovascular diseases. The high mortality and the...
Fangyuan Chen et al.
Journal of cardiovascular pharmacology, 63(6), 544-552 (2014-04-09)
This study aimed to investigate the effects of curcumin on macrophages polarization and possible mechanism involved, and to analyze the molecular basis of its antiatherosclerosis activity. RAW264.7 macrophages (M0) and M1 macrophages were treated with curcumin at 0, 6.25, 12.5...
Enas Alkhader et al.
AAPS PharmSciTech, 18(4), 1009-1018 (2016-09-02)
In the present study, we report the properties of a mucoadhesive chitosan-pectinate nanoparticulate formulation able to retain its integrity in the milieu of the upper gastrointestinal tract and subsequently, mucoadhere and release curcumin in colon conditions. Using this system, we...
Tao Zhou et al.
PloS one, 9(9), e107876-e107876 (2014-10-01)
Curcumin, a spice component as well as a traditional Asian medicine, has been reported to inhibit proliferation of a variety of cancer cells but is limited in application due to its low potency and bioavailability. Here, we have assessed the...
Fan Meng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 12-24 (2015-02-18)
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90 (PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene glycol 8000 (PEG) were used as hydrophilic polymers. CUR polymer miscibility was evaluated by solubility parameter, melting...
Ian M Williams et al.
Neurobiology of disease, 67, 9-17 (2014-03-19)
Niemann-Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder characterised by the storage of multiple lipids, reduced lysosomal calcium levels, impaired late endosome:lysosome fusion and neuroinflammation. NPC is caused by mutations in either of the two genes, NPC1...
Khajeelak Chiablaem et al.
Anticancer research, 34(4), 1857-1864 (2014-04-03)
Vasculogenic mimicry (VM) refers to the process in which highly invasive cancer cells mimic endothelial cells by forming blood channels. In the present study, we investigated the effect of curcumin, a natural product from turmeric, on VM of SK-Hep-1 human...
Seyung S Chung et al.
Anticancer research, 35(1), 39-46 (2015-01-01)
The cancer stem cell (CSC) model postulates the existence of a small proportion of cancer cells capable of sustaining tumor formation, self-renewal and differentiation. Signal Transducer and Activator of Transcription 3 (STAT3) signaling is known to be selectively activated in...
Maurizio Vitadello et al.
The Journal of physiology, 592(12), 2637-2652 (2014-04-09)
Antioxidant administration aimed to antagonize the development and progression of disuse muscle atrophy provided controversial results. Here we investigated the effects of curcumin, a vegetal polyphenol with pleiotropic biological activity, because of its ability to upregulate glucose-regulated protein 94 kDa...
Jeffrey M Witkin et al.
CNS & neurological disorders drug targets, 12(4), 487-497 (2013-04-12)
The root extract, curcumin (diferuloylmethane), is a constituent of the ancient herbal medicine Jiawei-Xiaoyaosan that has been used for dyspepsia, stress, and mood disorders. Curcumin engenders a diverse profile of biological actions that result in changes in oxidative stress, inflammation...
Mohammed Anwar et al.
International journal of pharmaceutics, 468(1-2), 158-164 (2014-04-22)
Nano-sized curcumin-loaded super-paramagnetic iron oxide nanoparticles (CUR-OA-SPIONs) were synthesized chemically by co-precipitation method using oleic acid as a stabilizer and Myrj 52 as a surfactant. The synthesized nanoparticles were characterized for their shape, size, surface morphology, electrokinetic potential, magnetic properties...
Abo Bakr Abdel Shakor et al.
Biochimica et biophysica acta, 1841(12), 1672-1682 (2014-09-23)
Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin-induced apoptosis was investigated in human leukemia HL60 cells and their HL60/VCR multidrug-resistant...
Dai-Ying Zhou et al.
Biological & pharmaceutical bulletin, 37(6), 1029-1034 (2014-03-22)
Four curcumin analogues ((2E,6E)-2,6-bis(thiophen-3-methylene) cyclohexanone (AS), (2E,5E)-2,5-bis(thiophen-3-methylene) cyclopentanone (BS), (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydropyran-4-one (ES) and (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydrothiopyran-4-one (FS) as shown in Fig. 1) with different linker groups were investigated for their effects in human prostate cancer CWR-22Rv1 and PC-3 cells. Compounds FS and ES...
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