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The level and distribution pattern of HP1beta in the embryonic brain correspond to those of H3K9me1/me2 but not of H3K9me3
Bartova E, et al.
Histochemistry and Cell Biology, 145(4), 447-461 (2016)
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair.
Okuchi, et al.
Nature Materials, 20, 108-118 (2021)
Hyesook Yoon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(7), 1483-1500 (2020-01-09)
Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of the thrombin receptor, also known as Protease Activated Receptor 1 (PAR1), accelerates myelin development. Here we demonstrate that
Baixuan He et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(10), 13361-13375 (2020-08-28)
Radiotherapy is one of the most effective treatments for head and neck tumors. However, delayed radiation-induced brain necrosis (RN) remains a serious issue due to the lack of satisfying prevention and effective treatment. The pathological role of radiation in the
Cole D Libner et al.
The Journal of comparative neurology, 528(10), 1704-1724 (2019-12-25)
Neurodegeneration, including loss of neurons and axons, is a feature of progressive forms of multiple sclerosis (MS). The mechanisms underlying neurodegeneration are mostly unknown. Research implicates autoimmunity to nonmyelin self-antigens as important contributors to disease pathogenesis. Data from our lab
A L Franklin et al.
Stain technology, 60(3), 125-135 (1985-05-01)
The antioxidant beta-mercaptoethanol (BME) used in conjunction with the permanent mountant DPX (DPX-BME) retarded fluorescent fading of mithramycin, acridine orange and Hoechst 33258 stained chicken erythrocytes, each to a varying degree. The initial fluorescence of all dyes examined was more
Roberta Parolisi et al.
Brain structure & function, 222(6), 2625-2639 (2017-02-27)
Adult neurogenesis has been implicated in brain plasticity and brain repair. In mammals, it is mostly restricted to specific brain regions and specific physiological functions. The function and evolutionary history of mammalian adult neurogenesis has been elusive so far. The
Karim A Sarhane et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(4), 1283-1295 (2019-05-31)
Functional recovery following nerve injury declines when target re-innervation is delayed. Currently, no intervention exists to improve outcomes after prolonged denervation. We explored the neuroregenerative effects of glial cell line-derived neurotrophic factor (GDNF) and chondroitinase (CDN) in a chronic denervation
Seyeon Oh et al.
Scientific reports, 11(1), 2012-2012 (2021-01-23)
Despite the advancement of targeted therapy for pulmonary arterial hypertension (PAH), poor prognosis remains a reality. Mesenchymal stem cells (MSCs) are one of the most clinically feasible alternative treatment options. We compared the treatment effects of adipose tissue (AD)-, bone
Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy.
Totola LT
The Journal of Physiology, 595 (2017)
Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T Cell Response Against Immunosuppressive Tumors
Viitala MK, et al.
Clinical Cancer Research, 145(4), 1-30 (2019)
Does 2, 4-dichlorophenoxyacetic acid (2, 4-D) induce genotoxic effects in tissue cultured Allium roots?
Ozkul M, et al.
Cytotechnology, 68(6), 2395-2405 (2016)
Paula Cunnea et al.
Scientific reports, 8(1), 14695-14695 (2018-10-04)
Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC). In this study, we suggest that profiling of tumour parameters such as bioelectrical-potential and
Camille N Pujol et al.
Science signaling, 13(618) (2020-02-13)
The serotonin (5-hydroxytrypatmine) receptor 5-HT6 (5-HT6R) has emerged as a promising target to alleviate the cognitive symptoms of neurodevelopmental diseases. We previously demonstrated that 5-HT6R finely controls key neurodevelopmental steps, including neuronal migration and the initiation of neurite growth, through
Natalie Landeck et al.
Molecular neurodegeneration, 15(1), 49-49 (2020-09-10)
α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson's disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contrast to
Alicja K Warda et al.
Frontiers in microbiology, 11, 69-69 (2020-02-23)
Significant evidence supports a relationship between the gut microbiome, inflammation, host response, and health, including the finding that a number of disorders are associated with disruption of the microbiome. In these disorders, a number of dietary interventions (including prebiotics, live
Christopher H Dillingham et al.
The Journal of comparative neurology, 525(17), 3742-3756 (2017-08-09)
The complex neuroanatomical connections of the inferior colliculus (IC) and its major subdivisions offer a juxtaposition of segregated processing streams with distinct organizational features. While the tonotopically layered central nucleus is well-documented, less is known about functional compartments in the
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Lucia Kořínková et al.
Journal of molecular endocrinology, 64(2), 77-90 (2019-12-20)
Lack of leptin production in ob/ob mice results in obesity and prediabetes that could be partly reversed by leptin supplementation. In the hypothalamus, leptin supports the production of prolactin-releasing peptide (PrRP), an anorexigenic neuropeptide synthesized and active in the brain.
null
Tomasz Dobrzycki et al.
Communications biology, 3(1), 71-71 (2020-02-15)
Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic endothelium (HE); misexpression of Gata2 leads to haematopoietic disorders. Here we deleted a conserved enhancer (i4 enhancer) driving pan-endothelial expression of the zebrafish
Motomasa Tanioka et al.
International journal of molecular sciences, 21(8) (2020-04-17)
Lipid emulsion was recently shown to attenuate cell death caused by excitotoxic conditions in the heart. There are key similarities between neurons and cardiomyocytes, such as excitability and conductibility, which yield vulnerability to excitotoxic conditions. However, systematic investigations on the
Morphological Changes in a Severe Model of Parkinson's Disease and Its Suitability to Test the Therapeutic Effects of Microencapsulated Neurotrophic Factors.
Requejo C
Molecular Neurobiology, 54 (2017)
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