MilliporeSigma
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Z694630

Nanofiber multiwell plate, Interactive MicroEnvironMent System (IMEMS)

size 6 wells, for co-culture, random oriented nanofibers

Synonym(s):
3d plates, tissue culture plates
NACRES:
NB.22

material

flat clear wells
polycaprolactone (PCL)

sterility

sterile

feature

lid

manufacturer/tradename

Nanofiber Solutions IMEM01

size

6 wells

suitability

suitable for (Tissue Engineering, Cancer Research)

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General description

Nanofiber cell culture dishes, multiwell plates and well plate inserts combine the best of 3D and 2D cell culture. The nanofibers are optically transparent to allow for live-cell imaging and real time quantification of cell mobility. The nanofibers mimic the 3D topography in vivo, and can be easily coated with ECM proteins for Cancer Research. The Cells can be simply removed for protein or gene analysis.

The nanofibers have higher expansion rates, better differentiation control, and has a synthetic surface with no animal contamination, ideal for stem cells research and immunohistochemistry staining. Nanofiber scaffolds can be easily shaped or sized, made from nearly any synthetic or natural polymer for customized tissue engineering. They can then be implanted in vivo or used in vitro. The standard plate dimensions available will work with current automated equipment for high throughput drug discovery needs.

The cell culture dishes, plates and inserts are available with either randomly oriented fibers or aligned fibers.

Features and Benefits

Interactive Microenvironment System (IMEMS)
  • Allows co-culture of several different cell types for enhanced interaction and cellular response
  • Cells have chemical communication, but not physical contact which allows easy post-analysis of each cell type
  • Each layer within the IMEMS allows for high-resolution imaging of the cells after the culture period

Certificate of Analysis

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Certificate of Origin

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Quotes and Ordering

Jin Nam et al.
Acta biomaterialia, 7(4), 1516-1524 (2010-11-27)
As the potential range of stem cell applications in tissue engineering continues to grow, the appropriate scaffolding choice is necessary to create tightly defined artificial microenvironments for each target organ. These microenvironments determine stem cell fate via control over differentiation.
Jin Nam et al.
Tissue engineering. Part A, 15(3), 513-523 (2008-08-13)
Mechanical training of engineered tissue constructs is believed necessary to improve regeneration of cartilaginous grafts. Nevertheless, molecular mechanisms underlying mechanical activation are not clear. This is partly due to unavailability of appropriate scaffolds allowing exposure of cells to dynamic compressive
Sara N Fischer et al.
Biomaterials, 32(2), 538-546 (2010-09-30)
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by irreversible scarring. Collagen deposition, myofibroblast expansion, and the development of fibroblastic foci are the hallmark pathological events. The origin and mechanism of recruitment of myofibroblasts, the key cell contributing

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