X1126

Sigma-Aldrich

Xylazine

≥99%

Synonym(s):
2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine
Empirical Formula (Hill Notation):
C12H16N2S
CAS Number:
Molecular Weight:
220.33
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥99%

storage temp.

−20°C

SMILES string

Cc1cccc(C)c1NC2=NCCCS2

InChI

1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

InChI key

BPICBUSOMSTKRF-UHFFFAOYSA-N

General description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

Application

Xylazine has been used to anaesthetise experimental animals.

Biochem/physiol Actions

Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.
α2-adrenoceptor agonist, sedative, muscle relaxant.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. X1126.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

hazcat

Acute Tox. 3 Oral

storage_class_code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice
Calderone L, et al.
Experimental Eye Research, 42(4), 331-337 (1986)
Hannah T Nickles et al.
American journal of physiology. Lung cellular and molecular physiology, 307(1), L27-L37 (2014-05-13)
The pathogenesis of ventilator-induced lung injury has predominantly been attributed to overdistension or mechanical opening and collapse of alveoli, whereas mechanical strain on the airways is rarely taken into consideration. Here, we hypothesized that mechanical ventilation may cause significant airway...
Imaging of rat optic nerve axons in vivo
Koch JC, et al.
Nature Protocols, 6(12), 1887-1887 (2011)
Naomi Van Gassen et al.
European journal of immunology, 45(5), 1482-1493 (2015-02-04)
Pancreas injury by partial duct ligation (PDL) activates a healing response, encompassing β-cell neogenesis and proliferation. Macrophages (MΦs) were recently shown to promote β-cell proliferation after PDL, but they remain poorly characterized. We assessed myeloid cell diversity and the factors...
Lactobacillus casei addition to a repletion diet-induced early normalisation of cytokine profils during a pneumococcal infection in malnourished mice
Salva S, et al.
Food and agricultural immunology, 19(3), 195-211 (2008)

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