SRP6506

Haptoglobin Plasma (MixedType) from human plasma

≥95% (SDS-PAGE)

• Synonym(s): Bp, Haptoglobin b-Chain, Hp, haptoglobin a-chain
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human plasma
• assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: monomer 200 kDa (Hp 2-1); monomer 400 kDa (Hp 2-2); monomer 86 kDa (Hp 1-1)
• packaging: pkg of 1 mg
• UniProt accession no.: P00738
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... HP(3240)

Description

General description

An acute-phase plasma protein found in human plasma at 100-300 mg/100 mL. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.

Physical form

Lyophilized as a salt-free solid.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable