MilliporeSigma
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SAB5200035

Sigma-Aldrich

Monoclonal Anti-HCN4 antibody produced in mouse

clone S114-10, 1 mg/mL, purified immunoglobulin

Synonym(s):
Anti-HCN4, S141-10, Anti-hyperpolarization activated cyclic nucleotide gated potassium channel 4
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S114-10, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 130 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... HCN4(59266)

General description

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4) is one of the subunits of hyperpolarization-activated cyclic nucleotide-gated channels, which have a role in synaptic transmission, dendritic integration, membrane and action potential. It is a heteromeric channel.[55][56] HCN4 is highly expressed in rat embryonic hearts, specifically in the sinoatrial node.[57][58]

Specificity

Detects ~130 kDa. No cross-reactivity against other HCNs

Immunogen

Fusion protein amino acids 1019-1198 (c-terminus) of rat HCN4, Accession Number Q9JKA7

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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