Anti-Claudin 5 Antibody detects endogenous levels of total Claudin 5 protein.
The CLDN5 (claudins) gene is mapped to human chromosome 22q11.21 and codes for a transmembrane protein, which is a component of tight junction. The protein is a part of blood-brain barrier. The encoded protein is 303 - 218 amino acids long.
The antiserum was produced against synthesized peptide derived from human Claudin 5.
Immunogen Range: 169-218
Anti-Claudin 5, C-Terminal antibody produced in rabbit has been used for intravascular perfusion labelling of vascular endothelial- cadherin and Immunofluorescence.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
The CLDN5 (claudins) gene encodes a component of tight junction and serves as a selective barrier for solutes and water. Upregulation of CLDN5 was observed in migraine. The expression of CLDN5 is reduced in lung squamous carcinoma. CLDN5 is known to increase p21 and decrease cyclin D1, leading to the retardation of cell cycle G1 to S transition. Cldn5 maintains homeostasis of the central nervous system, being a part of blood-brain barrier.
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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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