Connexin 43 (Cx43) is also known as GJA1 (gap junction protein α 1) and belongs to a large family of homologous connexin proteins. It has an intracellular N-terminus, four transmembrane domains, two extracellular loops, one cytoplasmic loop and an intracellular C-terminus. It is located on human chromosome 6q22-q23.
Anti-Connexin 43 Antibody detects endogenous levels of total Connexin 43 protein.
The antiserum was produced against synthesized peptide derived from human Connexin 43.
Immunogen Range: 226-275
Anti-Connexin 43 antibody has been used in immunohistochemistry.
Mutations in Connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. Connexin 43 participates in the multiplication and differentiation of mature T cells. It also participates in the secretion and manufacturing of cytokines. It helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.
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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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