All Photos(4)

PVP1

Sigma-Aldrich

Poly(vinylpyrrolidone)–Iodine complex

Synonym(s):
Povadyne antiseptic, PVP-I
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.85

Quality Level

form

powder

solubility

H2O: 100 mg/mL

Mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites
viruses
yeast

SMILES string

II.C=CN1CCCC1=O

InChI

1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;

InChI key

CPKVUHPKYQGHMW-UHFFFAOYSA-N

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Application

Poly(vinylpyrrolidone)–Iodine complex, or PVP-I, has been used to study microbial decontamination of human donor eyes and the inactivation of infectious hematopoietic necrosis virus.

Packaging

100, 500 g in glass bottle
1 kg in glass bottle

Biochem/physiol Actions

PVP-1 is used as a slow iodine release formulation that iodinates lipids and oxidizes cell compounds such as tyrosine sidechains. It is used as a carbon nanotube coating agent to improve water solubility.

Other Notes

An iodophor; "tamed iodine."
Keep container tightly closed in a dry and well-ventilated place.

Legal Information

Povadyne is a registered trademark of National Patent Development Corp.

Pictograms

CorrosionEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

212.0 °F - Not applicable

Flash Point(C)

> 100 °C - Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Emmanuella Guenova et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(2), 290-297 (2013-02-08)
There is a need for cheap and efficacious wound dressings in developing countries. Banana leaves have been described as an excellent, inexpensive, easily available dressing material in tropical countries. As a natural product, banana leaves are heavily contaminated with various
E Pels et al.
The British journal of ophthalmology, 83(9), 1019-1026 (1999-08-26)
Povidone-iodine (PVP -I) is applied for microbial decontamination of human eyes donated for transplantation. Concentrations and immersion times vary greatly. The effectiveness and toxicity of PVP-I were assessed for different decontamination protocols. Human donor eyes and corneas were immersed in
Ioannis Liakos et al.
Carbohydrate polymers, 92(1), 176-183 (2012-12-12)
Biodegradable polymeric materials based on blending aqueous dispersions of natural polymer sodium alginate (NaAlg) and povidone iodine (PVPI) complex, which allow controlled antiseptic release, are presented. The developed materials are either free standing NaAlg films or Ca(2+)-cross-linked alginate beads, which
W N Batts et al.
Applied and environmental microbiology, 57(5), 1379-1385 (1991-05-01)
The fish rhabdovirus infectious hematopoietic necrosis virus (IHNV) was rapidly inactivated by extremely low concentrations of iodine in water. A 99.9% virus reduction was obtained in 7.5 s when virus (10 PFU/ml) and iodine (0.1 mg/liter, final concentration) were combined
Gianluca Pellino et al.
BMC surgery, 12 Suppl 1, S31-S31 (2012-11-28)
Restorative proctocolectomy with ileopouch-anal anastomosis (IPAA) is the treatment of choice for intractable or complicated ulcerative colitis(UC). Elderly patients often present with acute colitis requiring emergent subtotal colectomy(SC). Frail patients are at risk of developing septic complications related to the

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