All Photos(1)




Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:

Quality Level


H2O: 1 mg/mL

Mode of action

cell membrane | interferes

antibiotic activity spectrum

Gram-negative bacteria

storage temp.




InChI key


Related Categories

Amino Acid Sequence


General description

Chemical structure: peptide


PGLa is a cationic antimicrobial peptide (AMP) originally isolated from frog. It has been shown to have antibacterial,1 antifungal,2 and antiviral,3 activities. It is used to study novel peptide fragments that originate from PGLa and multinucleated gastric mucosal cells of Xenopus laevis.

Biochem/physiol Actions

The precursors of PGLa are caerulein and xenopsin. The mechanism of action of PGLa against Gram-negative bacteria is disruption of the cellular lipid bilayer.4 It is used to induce transmembrane pore formation in lipid bilayers and bacterial cell membranes. It is used in combination with magainin 2 for a synergistic effect.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class Code

11 - Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Mareike Hartmann et al.
Antimicrobial agents and chemotherapy, 54(8), 3132-3142 (2010-06-10)
Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to examine the ultrastructural changes in bacteria induced by antimicrobial peptides (AMPs). Both the beta-stranded gramicidin S and the alpha-helical peptidyl-glycylleucine-carboxyamide (PGLa) are cationic amphiphilic AMPs known to interact
Marco Ieronimo et al.
Journal of the American Chemical Society, 132(26), 8822-8824 (2010-06-17)
(19)F NMR is a unique tool to examine the structure of fluorine-labeled peptides in their native cellular environment, due to an exquisite sensitivity and lack of natural abundance background. For solid-state NMR analysis, we isolated native membranes from erythrocyte ghosts
J Michael Conlon et al.
Peptides, 31(6), 989-994 (2010-03-17)
The Volcano clawed frog Xenopus amieti Kobel, du Pasquier, Fischberg, and Gloor, 1980, with a chromosome number of 2n=72, is believed to have undergone two rounds of genome duplication since evolving from a diploid ancestor. Nine peptides with differential antimicrobial
Theodore Parker et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 100(3), 603-610 (2012-01-31)
Sustained release formulations of a potent antithrombotic drug, cilostazol, in poly-(lactic acid-co-glycolic acid) (PLGA) matrices were created for luminal release from a novel drug-eluting stent utilizing reservoirs (RES TECHNOLOGY™). The crystallinity of cilostazol and the morphology of the cilostazol/polymer matrix
Vincent Milleret et al.
Acta biomaterialia, 8(12), 4349-4356 (2012-07-31)
Electrospun grafts have been widely investigated for vascular graft replacement due to their ease and compatibility with many natural and synthetic polymers. Here, the effect of the processing parameters on the scaffold's architecture and subsequent reactions of partially heparinized blood

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