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N7787

Sigma-Aldrich

NS3694

≥98%, powder

Synonym(s):

4-Chloro-2-[3-(3-trifluoromethyl-phenyl)-ureido]benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C15H10ClF3N2O3
CAS Number:
426834-38-0
Molecular Weight:
358.70
MDL number:
MFCD00249000
UNSPSC Code:
12352200
PubChem Substance ID:
24724557
NACRES:
NA.77

assay

≥98%

form

powder

solubility

DMSO: soluble 22 mg/mL
H2O: insoluble <5 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F

InChI

1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)

InChI key

GNCZTZCPXFDPLI-UHFFFAOYSA-N

Gene Information

human ... GRIK1(2897)

Application

NS3694 may be used as an apoptosis inhibitor to study the relationship between the cellular mechanisms controlled by amputation-induced myeloid lineage activity.

Biochem/physiol Actions

NS3694 can prevent the active apoptosome complex formation.
NS3694 is an Inhibitor of apoptosome formation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cindy X Kha et al.
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Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration. However, it has been reported
Developmental dependence for functional eye regrowth in Xenopus laevis.
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Neural regeneration research, 13(10), 1735-1737 (2018-08-24)
Jovany J Franco et al.
Molecular biology of the cell, 30(16), 1890-1899 (2019-02-21)
Epithelial wound healing requires a complex orchestration of cellular rearrangements and movements to restore tissue architecture and function after injury. While it is well known that mechanical forces can affect tissue morphogenesis and patterning, how the biophysical cues generated after
Yantao Zhao et al.
Journal of agricultural and food chemistry, 67(46), 12761-12769 (2019-11-02)
There is convincing evidence that consuming whole grains (WGs) may decrease the risk of colorectal cancer (CRC). Wheat bran (WB) is a rich source of dietary fiber and phytochemicals with health-promoting properties. However, the active components especially the interaction between
Can Aztekin et al.
Development (Cambridge, England), 147(3) (2020-01-29)
Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to promote tissue repair and regeneration. Here, we took advantage of naturally occurring tail
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