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M6885

Sigma-Aldrich

1-Methyluric acid

Synonym(s):
1-Methyl-2,6,8-trihydroxypurine, 1-U, 1MUA
Empirical Formula (Hill Notation):
C6H6N4O3
CAS Number:
Molecular Weight:
182.14
Beilstein:
195190
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.51

assay

≥98% (HPLC)

Quality Level

form

powder

solubility

1 M NaOH: 20 mg/mL, clear to slightly hazy

SMILES string

CN1C(=O)NC2=C(NC(=O)N2)C1=O

InChI

1S/C6H6N4O3/c1-10-4(11)2-3(9-6(10)13)8-5(12)7-2/h1H3,(H,9,13)(H2,7,8,12)

InChI key

QFDRTQONISXGJA-UHFFFAOYSA-N

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Application

1-Methyluric acid has been used:
  • for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
  • in turbidimetric assay of synthetic urine samples
  • as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay

Packaging

50, 100 mg in poly bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6885.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Certificate of Analysis

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Certificate of Origin

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