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[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate

≥97% (HPLC), powder

Empirical Formula (Hill Notation):
C56H78N16O12 · xC2H4O2 · yH2O
Molecular Weight:
1167.32 (anhydrous free base basis)
MDL number:
PubChem Substance ID:

Quality Level


≥97% (HPLC)



UniProt accession no.

storage temp.


SMILES string




InChI key


Gene Information

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Amino Acid Sequence



[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate has been used:
  • as an luteinizing hormone-releasing hormone (LHRH) agonist to synchronize a cohort of females rats
  • to synchronize naturally cycling rats
  • to induce ovulation as a gonadotropin-releasing hormone (GnRH) analogue and as a supplement in Galap extender to dilute qualified ejaculate

Biochem/physiol Actions

Potent LH-RH agonist in rats and mice; reversibly delays sexual maturation in rats, stimulates spawning activity in fish. GnRH ( gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.


Bottomless glass bottle. Contents are inside inserted fused cone.


Health hazard

Signal Word


Hazard Statements

Precautionary Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

More documents

Quotes and Ordering

Fertility of rat epididymal sperm after chemically and surgically induced sympathectomy
Kempinas WG, et al.
Biology of Reproduction, 59(4), 897-904 (1998)
W S Yeung et al.
General and comparative endocrinology, 89(3), 323-332 (1993-03-01)
The effects of ovine luteinizing hormone (oLH) and a synthetic analog of luteinizing hormone releasing hormone, des-Gly10 [D-Ala6]-LHRH ethylamide acetate salt (LHRH-A), on gonadal development and on in vitro steroidogenesis in the female phase of the protogynous sex-reversing Monopterus albus
Annette E Evans et al.
Oecologia, 192(4), 909-918 (2020-03-13)
Phenotypic plasticity can be an important adaptive response to climate change, particularly for dispersal-limited species. Temperature frequently alters developmental and phenotypic traits including morphology, behavior, and reproductive cycles. We often lack crucial information about if and how thermal conditions during
Motility, mitochondrial membrane potential and ATP content of rabbit spermatozoa stored in extender supplemented with GnRH analogue [des-Gly10, D-Ala6]-LH-RH ethylamide
Gogol P, et al.
Polish Journal of Veterinary Sciences, 17(4), 571-575 (2014)
E L Mumford et al.
Journal of animal science, 72(1), 174-177 (1994-01-01)
A lack of pituitary LH stores has been implicated as the cause of seasonal anestrus and failure to ovulate during the spring transition period in mares. In this experiment, 40 mares were used to study the effects of GnRH, estrogen

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