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H1664

Sigma-Aldrich

Hemokinin 1 human

≥98% (HPLC), solid

Synonym(s):

hHK-1

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About This Item

Empirical Formula (Hill Notation):
C54H82N14O14S
CAS Number:
491851-53-7
Molecular Weight:
1183.38
MDL number:
MFCD06656083
UNSPSC Code:
12352202
PubChem Substance ID:
329815175
NACRES:
NA.32

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

UniProt accession no.

Q86UU9

shipped in

wet ice

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](N)[C@@H](C)O)C(N)=O

InChI

1S/C54H84N14O14S/c1-30(2)24-38(51(79)64-35(46(58)74)21-23-83-5)63-44(73)27-59-48(76)39(25-33-14-8-6-9-15-33)66-52(80)40(26-34-16-10-7-11-17-34)67-50(78)37(19-20-42(56)71)65-53(81)41(29-69)68-47(75)31(3)61-49(77)36(18-12-13-22-55)62-43(72)28-60-54(82)45(57)32(4)70/h6-11,14-17,30-32,35-41,45,69-70H,12-13,18-29,55,57H2,1-5H3,(H2,56,71)(H2,58,74)(H,59,76)(H,60,82)(H,61,77)(H,62,72)(H,63,73)(H,64,79)(H,65,81)(H,66,80)(H,67,78)(H,68,75)/t31-,32+,35-,36-,37-,38-,39-,40-,41-,45-/m0/s1

InChI key

NYBLUYYRUFKGTB-XJCFQSCISA-N

Gene Information

human ... TAC4(255061)

Amino Acid Sequence

Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2

General description

Hemokinin 1 (HK1) is a a member of the tachykinin peptide family with broad expression, particularly in brain areas.

Biochem/physiol Actions

Hemokinin 1 (HK1) is an endogenous agonist for all tachykinin receptors. However, it is highly selective for the NK1 (neurokinin 1) receptor. HK1 and substance-P compete with each other for binding to NK1. HK1 is involved in the B-cell as well as T-cell development.
NK1 tachykinin receptor agonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Riccardo Patacchini et al.
Trends in pharmacological sciences, 25(1), 1-3 (2004-01-16)
The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have a widespread peripheral distribution and a tachykinin NK(1) receptor selectivity. This
R A Duffy et al.
Neuropharmacology, 45(2), 242-250 (2003-07-05)
Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1 has not been identified. Recent studies suggest HK-1 may have a role in immunological functions, but there
Nigel M Page et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(10), 6245-6250 (2003-04-30)
We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and
Yu Zhang et al.
Blood, 102(6), 2165-2172 (2003-06-07)
Hemokinin 1 (HK-1) is a new member of the tachykinin peptide family that is expressed in hematopoietic cells. Recent reports studying mouse, rat, and human orthologs of HK-1 demonstrate a broader distribution than originally reported. Our previous studies demonstrated that
Stanislas Grassin-Delyle et al.
Respiratory research, 11, 139-139 (2010-10-12)
Human hemokinin-1 (hHK-1) and endokinins are peptides of the tachykinin family encoded by the TAC4 gene. TAC4 and hHK-1 expression as well as effects of hHK-1 in the lung and airways remain however unknown and were explored in this study.

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