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G7127

Sigma-Aldrich

Guanosine 5′-diphosphate sodium salt

Type I, ≥96% (HPLC)

Synonym(s):
GDP
Empirical Formula (Hill Notation):
C10H15N5O11P2
CAS Number:
Molecular Weight:
443.20
MDL number:
PubChem Substance ID:
NACRES:
NA.51

Quality Level

type

Type I

assay

≥96% (HPLC)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1

InChI

1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;

InChI key

PVMPTWQLNDHIEV-UHFFFAOYSA-N

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Application

Guanosine 5′-diphosphate sodium salt has been used:
  • in GTP-γ-35S functional assays
  • in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding
  • in the expression and purification of recombinant proteins

Packaging

10 mg in glass bottle
25, 100, 500 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

More Documents

Quotes and Ordering

Articles

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Get to know the Tricarboxylic acid (TCA) cycle to better inform your research in biochemistry, metabolomics, or related fields concerned with this metabolic pathway and its enzymes, by-products, or intermediates.

Protocols

LC MS Analysis of Nucleotides Effect of pH

ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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