FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where a subunit has resemblance to LH (luteinizing hormone), hCG (human chorionic gonadotropin) and TSH (thyrotropin-releasing hormone), which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.
The α chain of FSH has 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland.
Follicle stimulating hormone (FSH) from human pituitary has been used for-
luteal cell proliferation assayculturing of preantral follicle cells obtained from micein vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice andculture of RAW264.7 cell line
- in vitro luteinization of Macaque granulosa cells
FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS). In male fetus and neonates, it facilitates the proliferation of Sertoli cells. In pubescent males, it stimulates spermatogonia to undergo mitosis.
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
Package size based on protein content
Two-chain glycoprotein hormone
Vial also contains 0.1 mg of salts from 0.05 M phosphate buffer, pH 7.4.