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E0778

Sigma-Aldrich

Ephrin-B2/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

ELF-2, Htk-L, LERK-5, NLERK-1

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About This Item

MDL number:
MFCD01867533
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

mouse

Quality Level

200

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt 49.6 kDa
 60-65 kDa by SDS-PAGE (reducing)

packaging

pkg of 200 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

P52800

storage temp.

−20°C

Gene Information

mouse ... Efnb2(13642)

Biochem/physiol Actions

Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA4, EphB1, EphB2, EphB3, and EphB4). Involved in pattern formation and morphogenesis. Ephrin-B2 can be detected on monocytes, mesangial cells, CD34+ stem cells, bone marrow fibroblasts, activated melanocytes and melanoma cells, and pre-artery endothelial cells.

Other Notes

Extracellular domain of mouse ephrin-B2 (amino acids 1-227) fused to the C-terminal 6X histidine-tagged Fc region of human IgG1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to bind immobilized recombinant mouse EphB2/Fc in ELISA.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Takahiro Sawada et al.
PloS one, 12(7), e0180785-e0180785 (2017-07-08)
We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal body growth. In the

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