D9891

Doxycycline hyclate

• Synonym(s): Doxycycline hydrochloride hemiethanolate hemihydrate
• Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₈ · HCl · 0.5H₂O · 0.5C₂H₆O
• CAS Number: 24390-14-5
• Molecular Weight: 512.94
• Beilstein: 5702728
• MDL number: MFCD07357237
• PubChem Substance ID: 57654124
• NACRES: NA.85

Properties

• Quality Level: 200
• biological source: synthetic
• assay: ≥93.5% (HPLC); 95.0-102.0% anhydrous basis (ethanol free based)
• form: powder
• color: yellow to yellow-green
• mp: ~201 °C
• solubility: water: soluble 50 mg/mL, clear, yellow-green
• Mode of action: protein synthesis | interferes
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycoplasma; parasites
• storage temp.: 2-8°C
• SMILES string: Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
• InChI: 1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1
• InChI key: HALQELOKLVRWRI-ZVACAFRPSA-N

Description

General description

Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.

Chemical structure: tetracycline

Application

Doxycycline hyclate has been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).

Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.

Packaging

1, 5, 10, 25, 100 g in glass bottle

Biochem/physiol Actions

Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK Germany: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US),Eyeshields,Gloves