D4422

Sigma-Aldrich

Docusate sodium salt

BioXtra, ≥99%

Synonym(s):
Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt, AOT, Sodium bis(2-ethylhexyl) sulfosuccinate, Sulfobutanedioic acid bis(2-ethylhexyl ester) sodium salt, ‘Dioctyl’ sulfosuccinate sodium salt, Bis(2-ethylhexyl) sulfosuccinate sodium salt
Empirical Formula (Hill Notation):
C20H37NaO7S
CAS Number:
Molecular Weight:
444.56
Beilstein/REAXYS Number:
4117588
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

description

anionic

product line

BioXtra

assay

≥99%

mol wt

444.56 g/mol

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

solubility

passes test (per USP)

cation traces

Al: ≤0.001%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.01%
Mg: ≤0.0005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

[Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S([O-])(=O)=O

InChI

1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1

InChI key

APSBXTVYXVQYAB-UHFFFAOYSA-M

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General description

Docusate sodium salt is an anionic surfactant.

Application

Docusate sodium salt has been used in a study to assess chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticals. It has also been used in a study to investigate different formulations for drug delivery through the nail plate.
Forms reverse micelles in hydrocarbon solvents; Suitable for the solubilization of the major myelin transmembrane proteolipid

Packaging

50, 100, 500 g in poly bottle

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

hazcat

Eye Dam. 1 - Skin Irrit. 2

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 2

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Zhengjin Jiang et al.
Journal of pharmaceutical and biomedical analysis, 61, 184-190 (2011-12-28)
Drug-induced phospholipidosis (PLD) is an excessive accumulation of polar phospholipids within cells as a result of medical treatment. Even though a direct link between in vitro drug-induced PLD and toxicity in humans has not yet been firmly established, the development...
Investigation of different formulations for drug delivery through the nail plate
Vejnovic, I., et al.
International Journal of Pharmaceutics, 386, 10-10 (2010)
Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres
Kokai, L., et al.
J. Controlled Release, 141, 9-9 (2010)
Nader Emami et al.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 41(5), 316-319 (2012-10-25)
Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to...
Marc-Elie Nader et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 146(3), 455-460 (2011-11-22)
(1) To evaluate the ototoxic potential of docusate sodium and mineral oil and (2) to compare the cerumenolytic properties of these agents to water and a commercially available product. Prospective animal study. Docusate sodium and mineral oil are being used...

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