N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.
Anti-N-Cadherin antibody is suitable for the following procedures:
- electron microscopy
- flow cytometry
- immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
- western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts
200 μL in glass bottle
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.
CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
Clone GC-4 is also known as GB-9.
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