Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

442R-1

Sigma-Aldrich

LEF1 (EP310) Rabbit Monoclonal Primary Antibody

Synonym(s):

Lymphoid Enhancing Factor 1

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP310, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (442R-14)
vial of 0.1 mL concentrate Research Use Only (442R-14-RUO)
vial of 0.5 mL concentrate (442R-15)
vial of 1.0 mL concentrate (442R-16)
vial of 1.0 mL concentrate Research Use Only (442R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (442R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (442R-17)
vial of 7.0 mL pre-dilute ready-to-use (442R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (442R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

small lymphocytic lymphoma, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... LEF1(51176)

General description

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family. LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells. Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas. Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kata Boras-Granic et al.
Developmental biology, 295(1), 219-231 (2006-05-09)
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appendages such as hair follicles and mammary glands. Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis. In order to define the role
Rajesh Kumar Gandhirajan et al.
Neoplasia (New York, N.Y.), 12(4), 326-335 (2010-04-03)
Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-1 might lead to killing of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service