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91707

Sigma-Aldrich

Trifluoroacetic acid

puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Synonym(s):
TFA
Linear Formula:
CF3COOH
CAS Number:
Molecular Weight:
114.02
Beilstein:
742035
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

vapor density

3.9 (vs air)

Quality Level

vapor pressure

97.5 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.0% (GC)

form

liquid

technique(s)

HPLC: suitable
LC/MS: suitable

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

pH

1 (20 °C, 1 g/L)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

water: soluble

density

1.489 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.1
λ: 280 nm Amax: 0.08
λ: 290 nm Amax: 0.07
λ: 300 nm Amax: 0.06
λ: 320 nm Amax: 0.05

suitability

corresponds to standard for RP gradient test

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

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General description

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.[30]

Application

Trifluoroacetic acid (TFA) may be used in the following studies:
  • Preparation of TFA reagent for the estimation of serum vitamin A.
[74]
  • To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
  • [75]
  • A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
  • [76]
  • Preparation of artemisinin under optimized reaction conditions.
  • [31]

    Packaging

    package with 10x1mL

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    Pictograms

    CorrosionExclamation mark

    Signal Word

    Danger

    Hazard Statements

    Hazard Classifications

    Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

    Storage Class Code

    8A - Combustible, corrosive hazardous materials

    WGK

    WGK 2

    Flash Point(F)

    212.0 °F - Pensky-Martens closed cup

    Flash Point(C)

    > 100 °C - Pensky-Martens closed cup

    Certificate of Analysis

    Enter Lot Number to search for Certificate of Analysis (COA).

    Certificate of Origin

    Enter Lot Number to search for Certificate of Origin (COO).

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