91707

Sigma-Aldrich

Trifluoroacetic acid

puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Synonym(s):
TFA
Linear Formula:
CF3COOH
CAS Number:
Molecular Weight:
114.02
Beilstein/REAXYS Number:
742035
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

vapor density

3.9 (vs air)

vapor pressure

97.5 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.0% (GC)

form

liquid

application(s)

HPLC: suitable
LC/MS: suitable

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

pH

1 (20 °C, 1  g/L)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

water: soluble

density

1.489 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.1
λ: 280 nm Amax: 0.05
λ: 290 nm Amax: 0.04
λ: 300 nm Amax: 0.03
λ: 320 nm Amax: 0.025

suitability

corresponds to standard for RP gradient test

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

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General description

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.

Application

Trifluoroacetic acid (TFA) may be used in the following studies:
  • Preparation of TFA reagent for the estimation of serum vitamin A.
  • To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
  • A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
  • Preparation of artemisinin under optimized reaction conditions.

Packaging

package with 10x1mL

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Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

hazcat

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

storage_class_code

8A - Combustible, corrosive hazardous materials

WGK Germany

WGK 2

Flash Point(F)

212.0 °F - Pensky-Martens closed cup

Flash Point(C)

> 100 °C - Pensky-Martens closed cup

Certificate of Analysis

Certificate of Origin

Guangfa Shi et al.
Organic letters, 17(1), 38-41 (2014-12-18)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in...
Risto Kostiainen et al.
Journal of chromatography. A, 1216(4), 685-699 (2008-09-19)
The most widely used ionization techniques in liquid chromatography-mass spectrometry (LC-MS) are electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI). All three provide user friendly coupling of LC to MS. Achieving optimal LC-MS conditions is...
W C Mahoney et al.
The Journal of biological chemistry, 255(23), 11199-11203 (1980-12-10)
A method employing reverse phase high performance liquid chromatography has been developed for the purification of large denatured peptides. The cyanogen bromide fragments of hemoglobin alpha, beta, and gamma chains (13 to 91 residues in length) could be separated and...
Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid.
J B NEELD et al.
The Journal of nutrition, 79, 454-462 (1963-04-01)
Continuous-flow synthesis of the anti-malaria drug artemisinin.
François Lévesque et al.
Angewandte Chemie (International ed. in English), 51(7), 1706-1709 (2012-01-18)
Protocols
Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.
Read More

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