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91707

Sigma-Aldrich

Trifluoroacetic acid

puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Synonym(s):
TFA
Linear Formula:
CF3COOH
CAS Number:
Molecular Weight:
114.02
Beilstein:
742035
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

vapor density

3.9 (vs air)

vapor pressure

97.5 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.0% (GC)

form

liquid

technique(s)

HPLC: suitable
LC/MS: suitable

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

pH

1 (20 °C, 1 g/L)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

water: soluble

density

1.489 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.1
λ: 280 nm Amax: 0.08
λ: 290 nm Amax: 0.07
λ: 300 nm Amax: 0.06
λ: 320 nm Amax: 0.05

suitability

corresponds to standard for RP gradient test

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

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General description

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.

Application

Trifluoroacetic acid (TFA) may be used in the following studies:
  • Preparation of TFA reagent for the estimation of serum vitamin A.
  • To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
  • A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
  • Preparation of artemisinin under optimized reaction conditions.

Packaging

package with 10x1mL

Recommended products

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Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

212.0 °F - Pensky-Martens closed cup

Flash Point(C)

> 100 °C - Pensky-Martens closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Protocols

Protocols for the Fmoc SPPS of Cysteine-containing Peptides

Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.

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