33209

Sigma-Aldrich

Acetic acid

glacial, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%

Synonym(s):
Glacial acetic acid
Linear Formula:
CH3CO2H
CAS Number:
Molecular Weight:
60.05
Beilstein/REAXYS Number:
506007
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

grade

ACS reagent
puriss. p.a.

Agency/Method

USP/NF
reag. ISO
reag. Ph. Eur.

vapor density

2.07 (vs air)

assay

≥99.8%

form

liquid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

application(s)

mass spectrometry (MS): suitable

impurities

≤0.0002% acetaldehyde
≤0.0005% non-volatile matter
≤0.002% KMnO4 red. matter (as HCOOH)
≤0.01% acetic anhydride (GC)
≤0.2% water (Karl Fischer)

color

APHA: ≤10

refractive index

n20/D 1.371 (lit.)

pH

2.5 (20 °C, 50  g/L)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

transition temp

freezing point ≥16.3 °C

density

1.049 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.5 mg/kg
phosphate (PO43-): ≤0.5 mg/kg
sulfate (SO42-): ≤0.5 mg/kg

cation traces

Ag: ≤0.01 mg/kg
Al: ≤0.05 mg/kg
As: ≤0.01 mg/kg
Ba: ≤0.01 mg/kg
Be: ≤0.01 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.2 mg/kg
Cd: ≤0.02 mg/kg
Co: ≤0.01 mg/kg
Cr: ≤0.05 mg/kg
Cu: ≤0.01 mg/kg
Fe: ≤0.2 mg/kg
Ge: ≤0.05 mg/kg
K: ≤0.1 mg/kg
Li: ≤0.01 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.01 mg/kg
Mo: ≤0.02 mg/kg
Na: ≤0.5 mg/kg
Ni: ≤0.05 mg/kg
Pb: ≤0.02 mg/kg
Sr: ≤0.01 mg/kg
Ti: ≤0.01 mg/kg
Tl: ≤0.05 mg/kg
V: ≤0.01 mg/kg
Zn: ≤0.05 mg/kg
Zr: ≤0.1 mg/kg

SMILES string

CC(O)=O

suitability

passes test for indifference to chromic acid

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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General description

Acetic acid is an organic carboxylic acid. It is a hygroscopic liquid having a pungent odor. Its anhydrous form is commonly referred as glacial acetic acid. It forms dimers linked by hydrogen bonds in solution and gaseous phases. It is weakly acidic in nature.

Application

Acetic acid has been used in the analysis of synthetic peptides by electron transfer dissociation (ETD) tandem mass spectrometry (MS/MS). It may be used in the preparation of peroxyacetic acid (disinfectant), via reaction with perhydrol (30% hydrogen peroxide).
for use as solvent for perchloric acid titration

Packaging

In PE-bottles; also available Glass-bottles (Material no. ending with *-GL)

Other Notes

The article number 33209-4X2.5L will be discontinued. Please order the single bottle 33209-2.5L which is physically identical with the same exact specifications.
The article number 33209-4X2.5L-M will be discontinued. Please order the single bottle 33209-2.5L-M which is physically identical with the same exact specifications.
The article number 33209-6X1L-M will be discontinued. Please order the single bottle 33209-1L-M which is physically identical with the same exact specifications.

Pictograms

FlameCorrosion

Signal Word

Danger

Hazard Statements

hazcat

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

102.2 °F

Flash Point(C)

39 °C

Certificate of Analysis

Certificate of Origin

John E P Syka et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9528-9533 (2004-06-24)
Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an electron to multiply protonated peptides in a radio frequency quadrupole linear ion trap (QLT) and induce fragmentation...
Qini Gan et al.
Journal of Alzheimer's disease : JAD, 70(4), 1025-1040 (2019-07-16)
Recent studies demonstrate that peripheral amylin treatment reduces pathology in mouse models of Alzheimer's disease (AD). However, soluble and aggregated amylin are distinct species; while amylin is a physiological neuropeptide, amylin aggregation is a pathological factor for diabetes. We thus...
Eagleson M.
Concise Encyclopedia Chemistry, 5-5 (1994)
Katharine Trenholme et al.
Antimicrobial agents and chemotherapy, 58(7), 3666-3678 (2014-04-16)
Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity; however, its use is limited by side effects. The development...
Isabelle Brunet et al.
The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue...

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