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Y0001413

Fulvestrant for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Fulvestrant, (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol, Faslodex, ICI 182,780, ZD 182780, ZD 9238, ZM 182780

Empirical Formula (Hill Notation):

C₃₂H₄₇F₅O₃S

CAS Number:

129453-61-8

Molecular Weight:

606.77

MDL number:

MFCD00903953

PubChem Substance ID:

329831412

NACRES:

NA.24

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Sigma-Aldrich

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grade

pharmaceutical primary standard

API family

fulvestrant

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc4cc(O)ccc24

InChI

1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1

InChI key

VWUXBMIQPBEWFH-WCCTWKNTSA-N

Gene Information

human ... ESR1(2099) , ESR2(2100)

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Show Differences

1 of 4

This Item	I4409	Y0001399	1286650
Y0001413 Fulvestrant for system suitability	Sigma-Aldrich I4409 Fulvestrant	Y0001399 Fulvestrant	USP 1286650 Fulvestrant
manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename EDQM	manufacturer/tradename USP
application(s) pharmaceutical (small molecule)	application(s) -	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format -	format neat	format neat
API family fulvestrant	API family -	API family fulvestrant	API family -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Fulvestrant (ICI 182,780) is a selective estrogen receptor down-regulator (SERD). Fulvestrant is a high affinity estrogen receptor antagonist. IC₅₀ = 0.29 nM. Fulvestrant is the first "pure" antiestrogen with no agonistic activity both in vitro and in vivo.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues.

Yan Xin et al.

Environmental science & technology, 53(14), 8371-8380 (2019-06-30)

As alternatives to perfluorooctanoic acid (PFOA), hexafluoropropylene oxide (HFPO) homologues, including hexafluoropropylene oxide dimer acid (HFPO-DA), hexafluoropropylene oxide trimer acid (HFPO-TA), and hexafluoropropylene oxide tetramer acid (HFPO-TeA), have been used in the fluoropolymer industry for a long period of time.

Fulvestrant, a selective estrogen receptor down-regulator, sensitizes estrogen receptor negative breast tumors to chemotherapy.

Donghai Jiang et al.

Cancer letters, 346(2), 292-299 (2014-01-28)

Drug resistance frequently results in poor prognosis and high 5-year recurrence rate in estrogen receptor-negative (ER-) breast cancer patients. Herein, we examined the reversal effects of fulvestrant on multidrug resistance (MDR) in ER- breast cancer cells. Co-administration of fulvestrant significantly

Is fulvestrant ("Faslodex") just another selective estrogen receptor modulator?

A Howell

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16 Suppl 2, 521-523 (2006-10-03)

Finding the right dose of fulvestrant in breast cancer.

L Estévez et al.

Cancer treatment reviews, 39(2), 136-141 (2012-07-17)

Fulvestrant is a selective estrogen receptor downregulator, behaving as a complete antagonist. It was initially approved, at a dose of 250 mg, to treat hormone dependant breast cancer in second line setting. However, a series of pharmacological and pre-clinical studies

Fulvestrant: expanding the endocrine treatment options for patients with hormone receptor-positive advanced breast cancer.

Stephen Chia et al.

Breast (Edinburgh, Scotland), 17 Suppl 3, S16-S21 (2008-03-21)

With the aromatase inhibitors (AIs) replacing tamoxifen as the first-line treatment for postmenopausal women with hormone receptor-positive early and advanced breast cancer, there is a need to evaluate appropriate endocrine treatment options following AI failure. However, until recently, there were

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