S6297

Sigma-Aldrich

Sodium bicarbonate

BioXtra, 99.5-100.5%

Synonym(s):
Sodium hydrogen carbonate
Linear Formula:
NaHCO3
CAS Number:
Molecular Weight:
84.01
Beilstein/REAXYS Number:
4153970
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

product line

BioXtra

Quality Level

assay

99.5-100.5%

form

powder

impurities

≤0.0005% Phosphorus (P)
≤0.015% Insoluble matter

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

solubility

H2O: 1 M, clear, colorless

density

2.16 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.003%
sulfate (SO42-): ≤0.003%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.005%
NH4+: ≤0.0005%
Pb: ≤0.0005%
Zn: ≤0.0005%

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

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NONH for all modes of transport

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WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Shay P McGuinness et al.
Critical care medicine, 41(7), 1599-1607 (2013-05-21)
Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute...
Joshua C Tremblay et al.
The Journal of physiology, 593(3), 723-737 (2014-11-25)
Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) is increased by acute hypoxia during rest by unknown mechanisms. Oral administration of acetazolamide blunts the pulmonary vascular pressure response to acute hypoxia, thus permitting the observation of IPAVA blood flow with minimal...
Roberto J Diaz et al.
American journal of physiology. Cell physiology, 306(12), C1191-C1199 (2014-04-25)
We have previously shown that ischemic preconditioning (IPC) protection against necrosis in whole hearts and in both fresh and cultured cardiomyocytes, as well as the improved regulatory volume decrease to hypoosmotic swelling in cardiomyocytes, is abrogated through Cl(-) channel blockade...
Sophia Zoungas et al.
Annals of internal medicine, 151(9), 631-638 (2009-11-04)
Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to...
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This...

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