RDD043

Acetylcholine chloride

≥99% (TLC), free-flowing, Redi-Dri^™

• Synonym(s): 2-Acetoxyethyltrimethylammonium chloride, Trimethyl(2-acetoxyethyl)ammonium chloride, ACh
• Linear Formula: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS Number: 60-31-1
• Molecular Weight: 181.66
• Beilstein/REAXYS Number: 3571875
• MDL number: MFCD00011698
• UNSPSC Code: 51151535
• NACRES: NA.25

Properties

• product line: Redi-Dri^™
• Quality Level: 100
• assay: ≥99% (TLC)
• form: powder
• quality: free-flowing
• packaging: pkg of 100 g
• color: white to faint yellow cast
• mp: 146-150 °C (lit.)
• solubility: H₂O: 100 mg/mL
• density: 1.27 g/cm³
• storage temp.: room temp
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M

Description

General description

Acetylcholine Chloride, the chloride salt of acetylcholine, is a synthetic amino alcohol with cholinergic properties, making it a vital component in biochemical and neurotransmission studies. It replicates the effects of the endogenous acetylcholine compound, which plays a significant role in the immune system, inflammation, and allergy research. Acetylcholine chloride acts as a cholinergic neurotransmitter, binding to nicotinic and muscarinic acetylcholine receptors, facilitating the opening of calcium channels.Furthermore, Acetylcholine chloride (ACh chloride) functions as a potent cholinergic agonist, influencing the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs). This feature is particularly relevant in studies related to the immune system and inflammation. Additionally, it demonstrates the capacity to inhibit the aggregation of p53 mutant peptide in vitro, which contributes to the exploration of biochemical and allergy research.

Application

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test
• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
• as a substrate for acetylcholinesterase
• to stimulate after discharge in Aplysia bag cell neurons

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Features and Benefits

• Redi-Dri^™ format for Improved Efficiency and Time Savings
• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Caution

Very hygroscopic

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable