PHR2932

Rosiglitazone

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Rosiglitazone, 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
• Linear Formula: C₁₈H₁₉N₃O₃S
• CAS Number: 122320-73-4
• Molecular Weight: 357.43
• MDL number: MFCD00871760

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Agency: traceable to USP 1605817
• API family: rosiglitazone
• form: solid
• packaging: pkg of 300 mg
• storage temp.: 2-8°C
• SMILES string: CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3
• InChI: 1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
• InChI key: YASAKCUCGLMORW-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable