PHR1490

Monoethanolamine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Ethanolamine, 2-Aminoethanol, 2-Aminoethyl alcohol, ETA, MEA, MEA 90, MEA-LCI, Monoethanolamine
• Linear Formula: NH₂CH₂CH₂OH
• CAS Number: 141-43-5
• Molecular Weight: 61.08
• Beilstein: 505944
• EC Number: 205-483-3
• MDL number: MFCD00008183

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. Y0001184; traceable to USP 1445925
• vapor density: 2.1 (vs air)
• vapor pressure: 0.2 mmHg ( 20 °C)
• description: Pharmaceutical Secondary Standard; Certified Reference Material
• CofA: current certificate can be downloaded
• autoignition temp.: 1436 °F
• expl. lim.: 17 %
• packaging: pkg of 1 mL
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.454 (lit.)
• bp: 170 °C (lit.); 69-70 °C/10 mmHg
• mp: 10-11 °C (lit.)
• density: 1.012 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: NCCO
• InChI: 1S/C2H7NO/c3-1-2-4/h4H,1-3H2
• InChI key: HZAXFHJVJLSVMW-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Monoethanolamine is majorly used in pharmaceutical formulations in the buffer systems, and emulsion preparations. It can also be used as a solvent for fats and oils and to synthesize many salts having therapeutic essence.

Application

Monoethanolamine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations and cosmetic products by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2076 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 + H312 + H332 - H314 - H335 - H412
• Precautionary Statements: P273 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): 195.8 °F - Pensky-Martens closed cup
• Flash Point(C): 91 °C - Pensky-Martens closed cup