PHR1292

Zidovudine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 3′-Azido-3′-deoxythymidine, AZT, Azidothymidine, ZDV, Zidovudine
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₄
• CAS Number: 30516-87-1
• Molecular Weight: 267.24
• Beilstein/REAXYS Number: 3595791
• MDL number: MFCD00006536
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823283

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to BP 803; traceable to Ph. Eur. Z1900000; traceable to USP 1724500
• API family: zidovudine
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 113-115 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
• InChI: 1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
• InChI key: HBOMLICNUCNMMY-XLPZGREQSA-N

Description

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

Zidovudine (AZT) is a thymidine analog anti-HIV drug, known to decrease the mortality rate in patients affected with HIV. The mode of action involves inhibiting the activity of viral reverse transcriptase and interrupting HIV replication.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Zidovudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, tablets and drug dosage forms by chromatography and spectrophotometric techniques.

Biochem/physiol Actions

Reverse transcriptase inhibitor active against HIV-1 virus.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0303 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H341 - H351
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Muta. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable