C1909

Citric acid monohydrate

ACS reagent, ≥99.0%

• Synonym(s): 2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
• Linear Formula: HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS Number: 5949-29-1
• Molecular Weight: 210.14
• Beilstein: 4018641
• EC Number: 201-069-1
• MDL number: MFCD00149972
• PubChem Substance ID: 24892446
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• Assay: ≥99.0%
• form: powder
• impurities: Substances carbonizable by hot sulfuric acid, passes test; ≤0.005% Insoluble matter
• ign. residue: ≤0.02%
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• solubility: H₂O: soluble 54 % (w/w) at 10 °C (Citric acid in water); H₂O: 59.2 % (w/w) at 20 °C (Citric acid in water); H₂O: 84.0 % (w/w) at 100 °C (Citric acid in water)
• anion traces: chloride (Cl^-): ≤0.001%; oxalate (C₂O₄^2-): passes test (limit about 0.05%); phosphate (PO₄^3-): ≤0.001%; sulfate (SO₄^2-): ≤0.002%
• cation traces: Fe: ≤3 ppm; Pb: ≤2 ppm
• SMILES string: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• InChI key: YASYEJJMZJALEJ-UHFFFAOYSA-N

Description

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be Δ_solH_m (298.15K, m = 0.0203molkg^-1) = (29061±123)Jmol^-1. It can be produced by crystallization from mother liquor of citric acid solution at 20-25°C during citric acid synthesis. An investigation of its crystal growth kinetics indicates that growth is linearly dependent on size.

Application

Citric acid monohydrate was used in the preparation of citric acid solution employed in the acetone method of ⁶⁸Ga pre-purification and radiolabeling technique.
It may be used:

• As release-modifying agent to improve the release of diltiazem hydrochloride from melt extruded Eudragit RS PO tablets.
• To prepare citrate buffer for use in the preparation of platelets for intravital microscopy.
• To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 345.0 °F
• Flash Point(C): 173.9 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves