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77253

Supelco

Heptafluorobutyric anhydride

for GC derivatization, LiChropur, ≥99.0%

Synonym(s):
HFAA, HFBA, Perfluorobutyric anhydride
Linear Formula:
(CF3CF2CF2CO)2O
CAS Number:
Molecular Weight:
410.06
Beilstein:
856036
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

assay

≥99.0% (GC)
≥99.0%

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.287 (lit.)

bp

108-110 °C (lit.)

mp

−43 °C (lit.)

density

1.674 g/mL at 20 °C (lit.)
1.674 g/mL at 20 °C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22

InChI key

UFFSXJKVKBQEHC-UHFFFAOYSA-N

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General description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

Application

Learn more in the Product Information

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Analysis Note

Suitable for derivatization of aldosterone, digoxin, digitoxin and metabolites, estradiol, postaglandins F and F2α, 3-oxo-Δ4-steroids, steroids and testosterone.

Other Notes

HFAA acylates amines, amino acids and other compounds. HFBA derivatives are highly volatile: used in GC separation
Reagent for 3-enol heptafluorobutyrate, heptafluorobutyrate, heptafluorobutyryl, 17-heptafluorobutyryl and 17-heptafluorobutyrate.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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