17849

Enrofloxacin

≥99.0%

• Synonym(s): Baytril
• Empirical Formula (Hill Notation): C₁₉H₂₂FN₃O₃
• CAS Number: 93106-60-6
• Molecular Weight: 359.39
• Beilstein: 5307824
• MDL number: MFCD00792463
• PubChem Substance ID: 329751571
• NACRES: NA.21

Properties

• Quality Level: 200
• assay: ≥99.0%; 99.0-101.0% (dried substance)
• form: powder or crystals
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• Mode of action: DNA synthesis | interferes; enzyme | inhibits
• SMILES string: CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
• InChI: 1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
• InChI key: SPFYMRJSYKOXGV-UHFFFAOYSA-N

Description

General description

Chemical structure: fluoroquinolone

Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.

Application

Enrofloxacin has been used:

• to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
• to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
• as an analyte in a chemiluminescence reagent system

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H317 - H334
• Precautionary Statements: P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves