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Boron trifluoride-methanol solution

~10% (~1.3 M), for GC derivatization, LiChropur

Linear Formula:
BF3 · MeOH
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


for GC derivatization



reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications


~10% (~1.3 M)


gas chromatography (GC): suitable


0.86 g/mL at 20 °C

storage temp.


SMILES string




InChI key


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General description

Boron trifluoride (BF3) is a Lewis acid; it is a very useful reagent for forming esters from acids. Boron trifluoride is commercially available as a 14% solution in methanol for forming esters derivatives. It catalysed reactions carried out in a water bath are very rapid and can be completed in a few minutes. Boron-trifluoride-catalysed transesterification of vegetable oils is one of the most popular methods. For transesterification of vegetable oils, BF3 is used in methanol (15 to 20% w/v).


Boron trifluoride-methanol solution may be used for catalysing a method, used for the synthesis of bishydroperoxides and their derivatives, based on a reaction of ketals with a solution of hydrogen peroxide in anhydrous ether. It may also be used for the rapid preparation of fatty acid esters for gas chromatographic analysis, as it converts fatty acids to their respective methyl esters in about 2 minutes.
Learn more in the Product Information
Suitable for derivatization of hydroxy fatty acids.

Other Notes

Reagent for methyl ester, O-acetyl.
Reagent for esterifying fatty acid for gas chromatographic analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word


Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK Germany


Flash Point(F)

49.5 °F

Flash Point(C)

9.7 °C

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

The rapid preparation of fatty acid esters for gas chromatographic analysis.
Metcalfe LD and Schmitz AA.
Analytical Chemistry, 33 (3), 363-364 (1961)
Christian F Ruiz et al.
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Journal of Chromatography A, 552, 281-281 (1991)
Introduction to Analytical Gas Chromatography, 219-219 (1997)
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Technology & Engineering, 123-124 (2007)

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