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AB5087

Sigma-Aldrich

Anti-Melanocyte Stimulating Hormone α Antibody

serum, Chemicon®

Synonym(s):

alpha-MSH, POMC, Pro-opiomelanocortin, Corticotropin-lipotropin precursor

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

sheep

Quality Level

300

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
radioimmunoassay: suitable

NCBI accession no.

NM_000939.2
NM_001035256.1

UniProt accession no.

P01189

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... POMC(5443)

Specificity

Specific for alpha-melanocyte stimulating hormone (aMSH), C-terminal.

Immunogen

MSH conjugated with bovine thyroglobulin.

Application

Anti-Melanocyte Stimulating Hormone Antibody, α detects level of Melanocyte Stimulating Hormone & has been published & validated for use in IH, RIA.
Immunohistochemistry: 1:10,000-1:50,000 on 4% paraformaldehyde fixed tissue.

RIA: 1:250,000-1:300,000.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
CNS Control of Metabolism

Hormones & Receptors

Physical form

Sheep Serum. Liquid. Contains no preservative.
Unpurified

Storage and Stability

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Hypothalamus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fasting differentially regulates expression of agouti-related peptide, pro-opiomelanocortin, prepro-orexin, and vasoactive intestinal polypeptide mRNAs in the hypothalamus of Japanese quail.
D Phillips-Singh, Q Li, S Takeuchi, T Ohkubo, P J Sharp, T Boswell
Cell and Tissue Research null
Nociceptin/orphanin FQ peptide in hypothalamic neurones associated with the control of feeding behaviour.
Maolood N, Meister B
Journal of Neuroendocrinology null
Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus.
P Ciofi, M Garret, O Lapirot, P Lafon, A Loyens, V Prevot, JE Levine
Endocrinology null
Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity.
Enxuan Jing, Eduardo A Nillni, Vanesa C Sanchez, Ronald C Stuart, Deborah J Good
Endocrinology null
Melanocortin 4 receptor-mediated hyperphagia and activation of neuropeptide Y expression in the dorsomedial hypothalamus during lactation
Chen, P. et al.
The Journal of Neuroscience, 24(22), 5091-5100 (2004)
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