AB3538P
Anti-Monocarboxylate Transporter 1 Antibody
Chemicon®, from rabbit
Synonym(s):
MCT1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SLC16A1(6566)
Specificity
Recognizes human Monocarboxylate Transporter 1 (MCT1). The immunogen shows no significant sequence homology with MCT2-8.
Immunogen
A 15 amino acid peptide sequence near the C-terminus of human MCT1 (Gerhart et al. 1997; Knott et al. 1999; Takanaga et al. 1995; Carpenter et al. 1996; Koehler-Stec et al. 1998; Yoon et al. 1999; Halestrap & Price 1999).
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
This Anti-Monocarboxylate Transporter 1 Antibody is validated for use in ELISA, WB for the detection of Monocarboxylate Transporter 1.
Western blot: 1-5 μg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.
Physical form
Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.
Gerhart, D Z, et al.
The American Journal of Physiology, 273, E207-E213 (1997)
Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle.
Arend Bonen, Miriam Heynen, Hideo Hatta
Applied Physiology, Nutrition, and Metabolism = Physiologie appliquee, Nutrition et metabolisme null
S-Nitrosation of monocarboxylate transporter 1: inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells.
Diers, AR; Broniowska, KA; Chang, CF; Hill, RB; Hogg, N
Free radical biology & medicine null
Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.
Vera Miranda-Gonçalves et al.
Oncotarget, 7(29), 46335-46353 (2016-06-23)
Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment through monocarboxylate transporters
Cellular assessment of muscle in COPD: case studies of two males.
HJ Green, E Bombardier, ME Burnett, S Iqbal, KA Webb, J Ouyang
International Journal of General Medicine null
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