8.52401

Fmoc-Asp(OEpe)-OH

Novabiochem^®

• Synonym(s): Fmoc-Asp(OEpe)-OH, N-α-Fmoc-(O-3-ethyl-pent-3-yl)aspartic acid
• Empirical Formula (Hill Notation): C₂₆H₃₁NO₆
• Molecular Weight: 453.53
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: carboxylic acid
• storage temp.: 15-25°C

Description

General description

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides. The bulky OEpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe group. The combination of Asp(OEpe) and the use of 1 M Oxyma Pure in DMF for Fmoc removal results in minimal aspartimde formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS

Analysis Note

Colour (visual): white to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable