All Photos(3)




hypergrade for LC-MS LiChrosolv®

Cyanomethane, Methyl cyanide, ACN, Ethyl nitrile
Linear Formula:
CAS Number:
Molecular Weight:
MDL number:
EC Index Number:

Quality Level

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)
97 hPa ( 20 °C)

product line



≥99.9% (GC)



autoignition temp.

524 °C
973 °F

expl. lim.

16 %


LC/MS: suitable


≤0.0001 meq/g Acidity
≤0.0002 meq/g Alkalinity
≤0.01% Water
≤10 ppb Al (Aluminium)
≤10 ppb Ca (Calcium)
≤10 ppb Fe (Iron)
≤10 ppb Mg (Magnesium)
≤5 ppb Any further metal (ICP-MS)
≤5 ppb K (Potassium)
≤50 ppb Na (Sodium)

evapn. residue

≤1.0 mg/L


APHA: ≤10


191 nm, ≥25%
195 nm, ≥85%
200 nm, ≥96%
215 nm, ≥98%
230 nm, ≥99%

refractive index

n20/D 1.344 (lit.)


81-82 °C (lit.)


−45 °C (lit.)

transition temp

flash point 2 °C


0.786 g/mL at 25 °C (lit.)

storage temp.


SMILES string




InChI key


Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

LiChrosolv hypergrade is accurately tested for LC-MS suitability, and meet all the requirements of modern LC-MS ionization methods (ESI/APCI - positive and negative mode). Thanks to their low level of ionic background and low ion suppression, LiChrosolv hypergrade solvents provide high reproducibility and high ionization efficiency. The packaging material has been improved to meet LC-MS quality requirements perfectly.

Preparation Note

Product filtered through a 0.2 μm filter

Analysis Note

Purity (GC): ≥ 99.9 %
Identity (IR): conforms
Evaporation residue: ≤ 1.0 mg/l
Water: ≤ 0.01 %
Color: ≤ 10 Hazen
Acidity: ≤ 0.0001 meq/g
Alkalinity: ≤ 0.0002 meq/g
Al (Aluminium): ≤ 10 ppb
Ca (Calcium): ≤ 10 ppb
Fe (Iron): ≤ 10 ppb
K (Potassium): ≤ 5 ppb
Mg (Magnesium): ≤ 10 ppb
Na (Sodium): ≤ 50 ppb
Any further metal (ICP-MS): ≤ 5 ppb
Gradient grade (at 210 nm): ≤ 1.0 mAU
Gradient grade (at 254 nm): ≤ 0.5 mAU
Fluorescence (as quinine at 254 nm): ≤ 1.0 ppb
Fluorescence (as quinine at 365 nm): ≤ 0.5 ppb
Transmission (at 191 nm): ≥ 25 %
Transmission (at 195 nm): ≥ 85 %
Transmission (at 200 nm): ≥ 96 %
Transmission (at 215 nm): ≥ 98 %
Transmission (from 230 nm): ≥ 99 %
Suitable for LC-MS; Intensity of background mass peak based on reserpine(APCI/ESI positive): ≤ 2 ppb
Suitable for LC-MS; Intensity of background mass peak based on reserpine(APCI/ESI negative): ≤ 20 ppb
Filtered by 0.2 µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany


FlameExclamation mark

Signal Word


Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids



Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

Certificate of Analysis

Certificate of Origin


Determination of Stevioside and Rebaudioside A in Stevia leaves, beverages and food additives using HPTLC-MS

HPTLC-MS was used to analyze stevioside and rebaudioside in artificial sweeteners, stevia plants, cola and isotonic drinks with a minimum of sample preparation.

Screening for Estrogen Active Nonylphenols in Water by Planar Solid Phase Extraction – Planar Yeast Estrogen Screen

Nonylphenols (NP) are ubiquitous substances that have been detected in highly diverse foodstuff. As breakdown products of nonylphenol ethoxylates, NP could end up in the aquatic environment. This article presents a rapid method for NP detection in surface water by planar solid phase extraction – planar yeast estrogen screen (pSPE-pYES).

UHPLC/MS Analysis of Diazepam and Metabolites on Titan™ C18, Comparison of Flow Rate and Column Length

Separation of Oxazepam; Desmethyldiazepam, analytical standard; Temazepam, analytical standard; Diazepam


Determination of Caffeine in Energy Drinks with HPTLC-MS

Thin layer chromatography coupled with mass spectrometry does not require substantial sample preparation. Energy drinks can be applied without dilution directly onto the TLC plate.

Determination of Lactose in Dairy Products Using TLC-MS

Straightforward HPTLC-MS analysis of lactose in dairy products (milk or yoghurt) using only protein crash, centrifugation and dilution as sample preparation.

Determination of Quinine in Tonic Water and Caffeine in Coffee and Cola Drinks Using TLC-MS

HPTLC–MS analysis of quinine in tonic water and caffeine in coffee and cola drinks. Tonic and cola drinks decarbonized through ultrasonication, and coffee extracted through PTFE filter.

BIOshell™ IgG 1000 Å C4 UHPLC Column for Improved Biomacromolecule Separations

BIOshell™ IgG 1000 Å C4 UHPLC Column for Improved Biomacromolecule Separations

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service