TRIC-A (trimeric intracellular cation channel type A), also known as Tmem38A, and sometimes NET1, is one of a number of TRIC channel subtypes that are believed to function as a Ca2+ counter-ion channel. TRIC-A is highly expressed in excitable cells and seems to work in coordination with Ca2+ release to balance transient negative potential. TRIC-A is located on the sarcoplasmic reticulum (SR) and is thought to be regulated by trans-membrane voltage. TRIC-A deficiency may lead to an abundance of Ca2+ and cause volatility in Ca2+ movement across the SR membrane.
This antibody recognizes the cytoplasmic domain of TRIC-A.
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRIC-A.
Anti-TRIC-A Antibody detects level of TRIC-A & has been published & validated for use in WB, IH & IC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).
Epigenetics & Nuclear Function
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TRIC-A on 10 µg of human fetal skeletal muscle tissue lysate.
~33 kDa observed
Purified rabbit polyclonal in PBS containing 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Human fetal skeletal muscle tissue lysate.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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