131305P

Sulfatides (Brain)

Avanti Research^™ - A Croda Brand

• Synonym(s): Cerebroside sulfates; Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0); 3-O-sulfo-β-D-C24-galactosylceramide (ammonium salt)
• CAS Number: 383906-24-9
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• description: Sulfatides (Brain, Porcine) (ammonium salt)
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 10 mg (131305P-10mg); pkg of 1 × 25 mg (131305P-25mg); pkg of 1 × 5 mg (131305P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]

Description

General description

Sulfatides are majorly present in the brain and plasma membrane, especially in the outer leaflet. They are anionic sulfoglycolipids synthesized by oligodendrocytes and are the prime component of myelin sheath. It constitutes 4 -7% weight of the myelin lipid. Sulfatides are also associated with non-neural tissues including gall bladder, colon and kidney. In the Golgi, 3′-phosphoadenosine5′phosphosulfate:cerebrosidesulfo transferase mediates the synthesis of sulfatides by 3-O-sulfation of the galactosylceramide. Lysosomes are the catabolism site for sulfatides, wherein arylsulfatase A mediates their breakdown.

This Natural Lipid is a mixture, and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

Application

Sulfatides (Brain) has been used:

• as a lipid standard in electrospray ionization (ESI)-MS/MS analysis, as an anionic amphiphile for large unilamellar vesicles (LUVs) preparation
• to test its myelin-associated axon growth inhibition functionality in retinal ganglion cells
• as a calibrant in tandem mass spectrometry to quantify mouse brain myelin samples

Biochem/physiol Actions

Elevated sulfatides levels are implicated in renal, ovarian and adenocarcinoma. Accumulation of sulfatides in events of arylsulfatase A enzyme deficiency leads to metachromatic leukodystrophy, a lysosomal storage disease. Sulfatide is a myelin-associated inhibitor of axon growth and is implicated in the axon regenerative failure. It is a multifunctional sulfolipid, which plays a key role in immune response and insulin secretion. It binds to fibrinogen and elicits anticoagulant activity. Sulfatides are elevated in Parkinson′s disease and is a target for nervous disorder treatment. Sulfatideis also an inhibitor of oligodendrocyte differentiation. Sulfatides are utilized by bacteria for their adherence into host cells. They are responsible for the inflammatory responses in chronic central nervous system illness.

Packaging

5 mL Amber Glass Screw Cap Vial (131305P-10mg)

5 mL Amber Glass Screw Cap Vial (131305P-25mg)

5 mL Amber Glass Screw Cap Vial (131305P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids