Seung-Ha Yang et al.
Experimental & molecular medicine, 41(5), 315-324 (2009-03-25)
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on T cells. Irradiated MSCs co-cultured with either na?ve or pre-activated...
Qi-Xiang Ye et al.
Experimental and therapeutic medicine, 14(3), 1884-1891 (2017-10-01)
Cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig) and anti-cluster of differentiation 154 (anti-CD154) are able to block B7/CD28 and CD40/CD154 co-stimulatory signals in T cells. Additionally, they promote hematopoietic stem cell transplantation (HSCT) in sensitized recipients and are able to induce...
Martin Böttcher et al.
Stem cells (Dayton, Ohio), 34(2), 516-521 (2015-10-21)
Mesenchymal stromal cells (MSCs) possess numerous regenerative and immune modulating functions. Transplantation across histocompatibility barriers is feasible due to their hypo-immunogenicity. MSCs have emerged as promising tools for treating graft-versus-host disease following allogeneic stem cell transplantation. It is well established...
Neda Milosavljevic et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 23(8), 1040-1050 (2017-05-10)
Mesenchymal stem cells (MSCs) are, due to immunomodulatory characteristics, considered as novel agents in the treatment of immune-mediated acute liver failure. Although it is known that MSCs can regulate activation of T lymphocytes, their capacity to modulate function of neutrophils...
Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2, 3 dioxygenase.
Vichaya, Elisabeth G et al.