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740292

Sigma-Aldrich

Vitamin D3 solution

100 μg/mL in ethanol, 97% (CP)

Synonym(s):
Cholecalciferol solution
Empirical Formula (Hill Notation):
C27H44O
CAS Number:
Molecular Weight:
384.64
EC Number:
MDL number:
eCl@ss:
34058003
PubChem Substance ID:
NACRES:
NA.24

Quality Level

assay

97% (CP)

form

solution

concentration

100 μg/mL in ethanol

application(s)

detection: suitable
mass spectrometry (MS): suitable

color

colorless

mp

-144.0 °C

storage temp.

−20°C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Gene Information

human ... VDR(7421)

General description

Vitamin D3 is also known as cholecalciferol which promotes the absorption of calcium and phosphorus in the body that regulates bone growth. It is commonly found in humans and animals produced on our skin when exposed to sunlight. It facilitates bone growth and mineralization indirectly by enhancing plasma calcium and phosphorus levels. It is synthesized from 7-dehydrocholesterol, a derivative of cholesterol.

Application

Vitamin D3 is used as an internal analytical standard for the quantitation of vitamin D3 concentration in dietary supplements, fortified foods or within a complex biological matrix using a variety of testing applications.
The active metabolite of vitamin D3 is calcitriol (1,25-dihydroxyvitamin D3) encapsulated into polymeric nanoparticles, which finds the application in vitamin D3-based chemotherapy formulation study and in vitro evaluation.

Packaging

1 mL in ampule

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

Nano-encapsulation of vitamin D 3 active metabolites for application in chemotherapy: formulation study and in vitro evaluation
Almouazen E, et al.
Pharmaceutical Research, 30(4), 1137-1146 (2013)
Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin
Holick, MF, et al.
Biochemical and biophysical research communications, 76(1), 107-114 (1977)
Anders Burild et al.
Steroids, 98, 72-79 (2015-03-01)
Information regarding the endogenous storages of vitamin D3 after cutaneous vitamin D synthesis compared to oral vitamin D3 supplementation is sparse. Furthermore it is not known whether vitamin D3 can be stored for later use during periods of shortages of...
Yuan-Hua Chen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(1), 90-97 (2015-02-13)
Several reports demonstrated that maternal lipopolysaccharide (LPS) exposure at middle gestational stage caused neural tube defects (NTDs). This study investigated the effects of supplementation with vitamin D3 (VitD3) during pregnancy on LPS-induced NTDs. Pregnant mice except controls were ip injected...
Stefan Pilz et al.
Hypertension (Dallas, Tex. : 1979), 65(6), 1195-1201 (2015-03-25)
Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values...

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