GLYMO, Glycidyl 3-(trimethoxysilyl)propyl ether, 3-(2,3-Epoxypropoxy)propyltrimethoxysilane
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level





refractive index

n20/D 1.429 (lit.)


120 °C/2 mmHg (lit.)


1.07 g/mL at 25 °C (lit.)

SMILES string




InChI key


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General description

(3-Glycidyloxypropyl)trimethoxysilane (GPTMS) is a bifunctional organosilane with three methoxy groups on one side and an epoxy ring on the other. The methoxy groups bind well with glass substrates creating a 3D matrix. The epoxy group is reactive with amides, alcohols, thiols and acids. GPTMS is highly reactive in water and can be used as a linking agent between the surface of the silica and the polymeric matrix.


Pre-treatment of carbon steel with 3-(Glycidoxypropyl)trimethoxysilane enhances the dry and wet adhesion while reducing the cathotic disbondment rate of an epoxy coating
GPTMS is widely used as a silica precursor. GPTMS alone with tetraethylortosilicate (TEOS) can be blended with chitosan for use as a filler for polymeric scaffold for bone tissue engineering. It can also be coated on the surface of aluminium alloy to protect from corrosion. GPTMS can used to functionalize (wrap) multi-walled carbon nanotubes (MWCNTs) which can be used as s a reinforcement in epoxy matrix nanocomposites.


1 L in glass bottle
100, 500 mL in Sure/Seal™



Signal Word


Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Certificate of Analysis

Certificate of Origin

  1. What can Product 440167, 3-Glycidyloxypropyl)trimethoxysilane GLYMO, be used for?

    According to Dow Corning®, 3-GLYCIDOXYPROPYLTRIMETHOXYSILANE can be used as a coupling agent for many thermoset resins with glass or  mineral fillers. Specifically, it has been used as a reinforcement treatment on glass fiber to improve physical properties (especially wet strength) or as  an adhesion promoter to improve the bonding of a polymer coating or adhesive to glass, metals or other polymeric surfaces.

  2. What is the viscosity of Product 440167 (3-Glycidyloxypropyl)trimethoxysilane GLYMO?

    This material is a low viscosity liquid with an average value of about 3 centistokes. Please note that this value is not part of our specifications.

  3. Where can I find more detailed information about how to use Product 440167. 3-Glycidyloxypropyl)trimethoxysilane, GLYMO, in adhesion/reinforcement applications?

    Dow Corning® has published a technical bulletin on this product, which is available by calling Technical Service at 800-231-8327.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Jadra Mosa et al.
Membranes, 9(9) (2019-08-30)
Organic/inorganic hybrid membranes that are based on GTT (GPTMS-TMES-TPTE) system while using 3-Glycidoxypropyl-trimethoxysilane (GPTMS), Trimethyletoxisilane (TMES), and Trimethylolpropane triglycidyl ether (TPTE) as precursors have been obtained while using a combination of organic polymerization and sol-gel synthesis to be used as...
Room temperature ionic liquids for epoxy nanocomposite synthesis: Direct dispersion and cure.
Throckmorton JA, et al.
Composites Science and Technology, 86(47), 38-44 (2013)
Ahmed A Nada et al.
International journal of biological macromolecules, 133, 538-544 (2019-04-22)
Homogenous allocation of inorganic particles in a polymeric matrix is a challenge. In this work, we discuss electrospinning of chitosan /gelatin using CS-Si (chitosan silicone hybrids) as well as the formation of homogeneously distributed Zn elements inside chitosan nanofiber through...
Organic-inorganic bonding in chitosan-silica hybrid networks: physical properties.
Trujillo, et al.
Journal of Polymer Science. Part B, Polymer Physics, 53(19), 1391-1400 (2015)
An assessment of the corrosion protection of AA2024-T3 treated with vinyltrimethoxysilane/(3-glycidyloxypropyl) trimethoxysilane.
Dalmoro V et al.
Corrosion Science, 92(19), 200-208 (2015)
Synthesis of Melting Gels Using Mono-Substituted and Di-Substituted Alkoxysiloxanes
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