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225517

Sigma-Aldrich

Methoxylamine hydrochloride solution

25-30 wt. % in H2O

Synonym(s):
O-Methylhydroxylamine hydrochloride
Linear Formula:
CH3ONH2 · HCl
CAS Number:
Molecular Weight:
83.52
Beilstein:
3589723
MDL number:
PubChem Substance ID:
NACRES:
NA.22

form

liquid

Quality Level

concentration

25-30 wt. % in H2O

refractive index

n20/D 1.4021

solubility

alcohol: soluble(lit.)
water: soluble(lit.)

density

1.1 g/mL at 25 °C

SMILES string

Cl[H].CON

InChI

1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H

InChI key

XNXVOSBNFZWHBV-UHFFFAOYSA-N

Application

Methoxylamine hydrochloride was used as an derivatization agent during the structural investigation of novel epoxyisoprostane phospholipid in mildly oxidized low density lipoprotien.

Packaging

25, 100 g in glass bottle

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

A D Watson et al.
The Journal of biological chemistry, 274(35), 24787-24798 (1999-08-24)
One of the earliest steps in the development of the atherosclerotic lesion is the accumulation of monocyte/macrophages within the vessel wall. Oxidized lipids present in minimally modified-low density lipoproteins (MM-LDL) contribute to this process by activating endothelial cells to express
Yanlin Jiang et al.
DNA repair, 8(11), 1273-1282 (2009-09-04)
Oxidative DNA damage has been implicated in a number of central nervous system pathologies. The base excision repair (BER) pathway is one of the most important cellular protection mechanisms that respond to oxidative DNA damage. Human apurinic (apyrimidinic) endonuclease/redox effector
Melissa L Fishel et al.
Molecular aspects of medicine, 28(3-4), 375-395 (2007-06-15)
With our growing understanding of the pathways involved in cell proliferation and signaling, targeted therapies, in the treatment of cancer are entering the clinical arena. New and emerging targets are proteins involved in DNA repair pathways. Inhibition of various proteins
Timothy J Kinsella
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(6), 1853-1859 (2009-02-26)
DNA damage processing by mismatch repair (MMR) and/or base excision repair (BER) can determine the therapeutic index following treatment of human cancers using radiation therapy and several classes of chemotherapy drugs. Over the last decade, basic and translational cancer research
Eva M Goellner et al.
Cancer research, 71(6), 2308-2317 (2011-03-17)
Glioblastoma multiforme (GBM) is a devastating brain tumor with poor prognosis and low median survival time. Standard treatment includes radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). However, a large percentage of tumors are resistant to the cytotoxic

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