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(±)-Propylene oxide

ReagentPlus®, ≥99%

(±)-Methyloxirane, 1,2-Epoxypropane
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

vapor density

2 (vs air)

vapor pressure

29.43 psi ( 55 °C)
8.59 psi ( 20 °C)

product line




autoignition temp.

1378 °F

expl. lim.

37 %

refractive index

n20/D 1.366 (lit.)


34 °C (lit.)


−112 °C (lit.)


0.83 g/mL at 25 °C (lit.)

SMILES string




InChI key


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General description

(±)-Propylene oxide is an organic compound used as an intermediate in several chemical reactions. It readily reacts with active hydrogen atoms.


Used in the production of polyether polyols, propylene glycols, propylene glycol ethers.Used as an intermediate to produce ammonium type complex to remove thin films of petroleum from water surfaces.


100, 500 mL in Sure/Seal™
1 L in Sure/Seal™
18 L in Kilo-Lab™

Other Notes

The article number 110205-4X1L will be discontinued. Please order the single bottle 110205-1L which is physically identical with the same exact specifications.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Signal Word


Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 1 - Muta. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids



Flash Point(F)

-36.4 °F - Equilibrium method

Flash Point(C)

-38 °C - Equilibrium method

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Josep Casamada Ribot et al.
Chemical communications (Cambridge, England), 46(37), 6971-6973 (2010-08-24)
The aqueous gelation of a quaternary ammonium oligo(propylene oxide)-based ionic liquid yields ion gels with a reverse thermoresponsive behavior (i.e., mechanical moduli and viscosity increase with temperature) and enhanced ionic conductivities.
Denis Merlet et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 209(2), 315-322 (2011-02-25)
The application of the G-SERFph pulse sequence is presented on enantiomeric mixtures dissolved in a chiral liquid crystal. It aims at editing, within one single 2D spectrum, every proton coupling which is experienced by a given proton site in the
Aude Bouchet et al.
The Journal of organic chemistry, 76(10), 4178-4181 (2011-04-08)
ECD and NMR experiments show that the complexation of propylene oxide (PrO) within the cavity of an enantiopure water-soluble cryptophane 1 in NaOH solution is enantioselective and that the (R)-PrO@PP-1 diastereomer is more stable than the (S)-PrO@PP-1 diastereomer with a
Sascha Brunke et al.
PLoS pathogens, 10(10), e1004478-e1004478 (2014-10-31)
Candida glabrata is one of the most common causes of candidemia, a life-threatening, systemic fungal infection, and is surpassed in frequency only by Candida albicans. Major factors contributing to the success of this opportunistic pathogen include its ability to readily
Javix Thomas et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(16), 4582-4587 (2011-03-25)
Chirality recognition in the hydrogen-bonded glycidol···propylene oxide complex has been studied by using rotational spectroscopy and ab initio calculations. An extensive conformational search has been performed for this binary adduct at the MP2/6-311++G(d,p) level of theory and a total of

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