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Dale Boger

Professor Dale Boger

As the exploration of the properties of complex natural products becomes increasingly more sophisticated with the technological advances being made in their screening and evaluation and as structural details of their interaction with biological targets becomes more accessible, the importance and opportunities for providing unique solutions to complex biological problems has grown. The Boger Lab addresses these challenging problems by understanding the complex solutions and subtle design elements that nature has provided in the form of a natural product and work to extend the solution through rational design elements to provide more selective, more efficacious, or more potent agents designed specifically for the problem or target under investigation. The resulting efforts have reduced many difficult or intractable synthetic challenges to manageable problems providing an approach not only to the natural product but one capable of simple extrapolation to a series of structural analogs with improved selectivity and efficacy.

The research interests of the Boger group include the total synthesis of biologically active natural products, the development of new synthetic methods, heterocyclic chemistry, bioorganic and medicinal chemistry, combinatorial chemistry, the study of DNA-agent interactions, and the chemistry of antitumor antibiotics. We place a special emphasis on investigations to define the structure-function relationships of natural or designed agents in efforts to understand the origin of their biological properties.

Boger Group Website

Recent papers from the Boger Group

1.
Burke CP, Haq N, Boger DL. 2010. Total Synthesis, Assignment of the Relative and Absolute Stereochemistry, and Structural Reassignment of Phostriecin (aka Sultriecin). J. Am. Chem. Soc.. 132(7):2157-2159. http://dx.doi.org/10.1021/ja9097252
2.
Shimamura H, Breazzano SP, Garfunkle J, Kimball FS, Trzupek JD, Boger DL. 2010. Total Synthesis of Complestatin: Development of a Pd(0)-Mediated Indole Annulation for Macrocyclization. J. Am. Chem. Soc.. 132(22):7776-7783. http://dx.doi.org/10.1021/ja102304p
Products available from the Boger Laboratory
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DISCIPLINES

  • Chemical Biology
  • Organic Synthetic Chemistry

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