- NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice.
NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice.
The Journal of endocrinology (2017-10-20)
E Meimaridou, M Goldsworthy, V Chortis, E Fragouli, P A Foster, W Arlt, R Cox, L A Metherell
PMID29046340
摘要
Nicotinamide nucleotide transhydrogenase, NNT, is a ubiquitous protein of the inner mitochondrial membrane with a key role in mitochondrial redox balance. NNT produces high concentrations of NADPH for detoxification of reactive oxygen species by glutathione and thioredoxin pathways. In humans, NNT dysfunction leads to an adrenal-specific disorder, glucocorticoid deficiency. Certain substrains of C57BL/6 mice contain a spontaneously occurring inactivating
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