A novel redox regulator, MnTnBuOE-2-PyP

A novel redox regulator, MnTnBuOE-2-PyP

Redox biology (2017-02-24)

Y Zhao, D W Carroll, Y You, L Chaiswing, R Wen, I Batinic-Haberle, S Bondada, Y Liang, D K St Clair

摘要

The signaling of reactive oxygen species (ROS) is essential for the maintenance of normal cellular function. However, whether and how ROS regulate stem cells are unclear. Here, we demonstrate that, in transgenic mice expressing the human manganese superoxide dismutase (MnSOD) gene, a scavenger of ROS in mitochondria, the number and function of mouse hematopoietic stem/progenitor cells (HSPC) under physiological conditions are enhanced. Importantly, giving MnTnBuOE-2-PyP

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腺苷 5′-三磷酸 (ATP) 生物发光体细胞检测试剂盒, for cellular ATP determination