- Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
Proceedings of the National Academy of Sciences of the United States of America (2017-02-06)
Fredrik H Sterky, Justin H Trotter, Sung-Jin Lee, Christian V Recktenwald, Xiao Du, Bo Zhou, Peng Zhou, Jochen Schwenk, Bernd Fakler, Thomas C Südhof
PMID28154140
摘要
Establishment, specification, and validation of synaptic connections are thought to be mediated by interactions between pre- and postsynaptic cell-adhesion molecules. Arguably, the best-characterized transsynaptic interactions are formed by presynaptic neurexins, which bind to diverse postsynaptic ligands. In a proteomic screen of neurexin-1 (Nrxn1) complexes immunoisolated from mouse brain, we identified carbonic anhydrase-related proteins CA10 and CA11, two homologous, secreted glycoproteins of unknown function that are predominantly expressed in brain. We found that CA10 directly binds in a