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Merck
  • Total synthesis of clavilactone B: a radical cyclization-fragmentation strategy.

Total synthesis of clavilactone B: a radical cyclization-fragmentation strategy.

Organic letters (2014-12-17)
Hiroshi Suizu, Daisuke Shigeoka, Hiroshi Aoyama, Takehiko Yoshimitsu
摘要

A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.

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钐, −40 mesh, 99% trace rare earth metals basis